TMEM45A - transmembrane protein 45A Gene

Also Known as DERP7; DNAPTP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55076

About TMEM45A

Cytogenetic location: 3q12.2 Genomic coordinates (GRCh38): 3:100,492,619-100,577,444 (from NCBI)

This gene has 7 transcripts (splice variants), 221 orthologues and 2 paralogues. Biased expression in skin (RPKM 215.6), liver (RPKM 25.9) and 2 other tissues.

Summary

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM45A Products (2)

mRNA Protein Name
NM_001363876.2 NP_001350805.1 transmembrane protein 45A isoform 1
NM_018004.3 NP_060474.1 transmembrane protein 45A isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM45A Protein Structure

DUF716

DUF716: Family of unknown function (DUF716) (118 - 242)

  • 0
  • 100
  • 200
  • 275 a.a.
Protein Preferred Names Protein Names

transmembrane protein 45A

  • DNA polymerase-transactivated protein 4

TMEM45A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM45A Q9NWC5 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
TMEM45A Q9NWC5 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
TMEM45A Q9NWC5 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
TMEM45A Q9NWC5 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pollen Allergy

  • Hay Fever
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14726 TMEM45A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21264 Tmem45a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27783 Tmem45a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TMEM45A MGD MGI:1913122
Canis familiaris TMEM45A VGNC VGNC:47582
Felis catus TMEM45A VGNC VGNC:66348
Rattus norvegicus TMEM45A RGD RGD:6495353
Macaca mulatta TMEM45A VGNC VGNC:79499
Others TMEM45A NCBI