CAPN5 - calpain 5 Gene

Also Known as VRNI; ADNIV; HTRA3; nCL-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 726

About CAPN5

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:77,066,971-77,126,155 (from NCBI)

This gene has 8 transcripts (splice variants), 286 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in colon (RPKM 33.5), duodenum (RPKM 28.3) and 19 other tissues.

Summary

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]

CAPN5 Products (1)

mRNA Protein Name
NM_004055.5 NP_004046.2 calpain-5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
23055945 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPN5 Protein Structure

Peptidase_C2

Peptidase_C2: Calpain family cysteine protease (26 - 342)

Calpain_III

Calpain_III: Calpain large subunit, domain III (353 - 495)

C2

C2: C2 domain (520 - 595)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 640 a.a.
Protein Preferred Names Protein Names

calpain-5

  • calpain htra-3

CAPN5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAPN5 O15484 STIP1 Homo sapiens P31948
Anti Tag CoIP
33961781
Intra
CAPN5 O15484 STIP1 Homo sapiens P31948
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vitreoretinopathy, Neovascular Inflammatory

  • Proliferative Vitreoretinopathy

  • Adniv

  • Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy

  • VRNI

  • Pvr

  • Neovascular Inflammatory Vitreoretinopathy

  • Vitreoretinopathy, Neovascular Inflammatory, Autosomal Dominant

  • Retinitis Proliferans

  • Neovascular Inflammatory Vitreoretinopathy Autosomal Dominant

  • Vitreoretinopathy Proliferative

  • Vitreoretinopathy, Proliferative

  • Proliferative Vitreo-Retinopathy
Vitreoretinopathy
Uveitis
Posterior Uveitis

  • Uveitis, Posterior

  • Choroiditis

  • Uveitis Posterior
Vitreous Disease

  • Disorder Of Vitreous Body
Macular Dystrophy, Dominant Cystoid

  • Cystoid Macular Edema

  • DCMD

  • Cystoid Macular Dystrophy

  • Macular Edema, Cystoid

  • Autosomal Dominant Cystoid Macular Edema

  • Cymd

  • Mddc

  • Familial Macular Edema

  • Macular Edema

  • Macular Retinal Edema
Retinal Detachment

  • Retinal Detachments

  • Rhegmatogenous Retinal Detachment

  • Ruptured Retina With Detachment

  • Retinal Hole With Detachment
Neovascular Glaucoma

  • Glaucoma, Neovascular

  • Secondary Angle-Closure Glaucoma With Rubeosis

  • Glaucoma Neovascular
Vitreoretinal Dystrophy

  • Vitreoretinal Dystrophies
Neuroretinitis

  • Juxtapapillary Focal Retinitis And Retinochoroiditis

  • Retinitis

  • Focal Retinitis And Retinochoroiditis, Juxtapapillary

  • Papilloretinitis
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Autoimmune Uveitis
Retinal Degeneration

  • Degeneration Of Retina
Retinal Perforation

  • Retinal Break

  • Retinal Perforations

  • Retinal Dialysis

  • Retinal Tear

  • Retinal Break Nos

  • Ruptured Retina
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Neuronal Ceroid Lipofuscinosis

  • Hereditary Ceroid Lipofuscinosis

  • Batten Disease

  • Ncl

  • Neuronal Ceroid-Lipofuscinoses

  • Lipofuscinosis, Ceroid, Neuronal

  • Juvenile Neuronal Ceroid Lipofuscinosis

  • Cerebromacular Dystrophy

  • Cerebromacular Degeneration

  • Ceroid-Lipofuscinosis

  • Ncl - [Neuronal Ceroid Lipofuscinosis]

  • Amaurotic Familial Idiocy

  • Amaurotic Idiocy

  • Amaurotic Idiot

  • Neuronal Lipofuscinosis

  • Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01891 CAPN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20869 Capn5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27386 Capn5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CAPN5 VGNC VGNC:38705
Macaca mulatta CAPN5 VGNC VGNC:70534
Bos taurus CAPN5 VGNC VGNC:26748
Felis catus CAPN5 VGNC VGNC:60355
Rattus norvegicus CAPN5 RGD RGD:620084
Mus musculus CAPN5 MGD MGI:1100859
Others CAPN5 NCBI