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Cat. No.: HY-P991734A

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VHB937 (IgG1-LALA)

VHB937 (IgG1-LALA) is a derivative of VHB937 (HY-P991734). VHB937 is a human monoclonal antibody that acts as a potent and selective TREM2 agonist. VHB937 enhances the surface expression of TREM2 and its downstream signaling pathways, such as Syk phosphorylation and calcium mobilization. VHB937 has demonstrated significant neuroprotective effects in various animal models of neuroinflammation and neurodegeneration, effectively alleviating pathological damage and reducing pro-inflammatory marker levels. VHB937 can be used in research related to neurodegenerative diseases.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VHB937 (IgG1-LALA) Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Chemical Information

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Stangel M, et al. VHB937, a TREM2 stabilizing and activating antibody strongly reduces pathology after peripheral administration in a broad range of animal models for neuroinflammation and neurodegeneration (P4-4.004). Neurology. 2024;102(7_supplement_1).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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