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Cat. No.: HY-184671

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VHL Ligand 41-CO-C10-NH2

VHL Ligand 41-CO-C10-NH2 is an E3 ligase ligand-linker conjugate for PROTAC synthesis. VHL Ligand 41-CO-C10-NH2 is the E3 ligase ligand-linker conjugate moiety of PROTAC BRD4 Degrader-3 (HY-135558).

For research use only. We do not sell to patients.

CAS No.: 2313233-96-2
Formula: C₃₂H₄₉N₅O₅S
Molecular Weight:615.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VHL Ligand 41-CO-C10-NH2 Chemical Structure

CAS No.: 2313233-96-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

VHL

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

VHL Ligand 41-CO-C10-NH2 is the E3 ligase ligand-linker conjugate of PROTAC BRD4 Degrader-3 (HY-135558), PROTAC BRD4 Degrader-3 (compound 1004.1) is an efficient PROTAC linked by von Hippel-Lindau ligand and BRD4 ligand^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2313233-96-2
Molecular Weight 615.83
Formula C₃₂H₄₉N₅O₅S
SMILES

NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]1O)[C@@H](C1)C(NOC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dragovich P, et al. (4-hydroxypyrrolidin-2-yl)-hydroxamate compounds and methods of use thereof. WO2019084030A1. WIPO; 2019 May 2.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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