2. Stem Cell/Wnt
  3. YAP
  4. VT104

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 2417718-25-1

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
500 mg 해외재고보유
1 g 해외재고보유
5 g   견적 받기  
10 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of VT104:

VT104 Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
RT-PCR
IP

    VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.

    Dose response curves of VT104 (0.001-10 μM) in SCEACono2 (ONO2) cells examined in proliferation assay and clonogenic assay.

    VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.

    qPCR for YAP/TAZ-TEAD target genes upon treatment with VT104 (1 µM) for 24 hours in ONO2 cells in vitro (n=3).

    VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.

    YAP co-immunoprecipitation experiment in ONO2 cells treated with VT104 (1µM) for 24 hours.

    View All YAP Isoform Specific Products:

    View All Isoforms
    YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    NCI-H226 IC50
    0.042 μM
    Compound: VT-104
    Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
    Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
    		[PMID: 35763499]
    In Vitro

    VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    VT104 Related Antibodies
    In Vivo

    VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NCI-H226-tumor bearing mice[1]
    Dosage: 0.3, 1, and 3 mg/kg
    Administration: Oral administration
    Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner.
    분자량

    420.43

    화학식

    C25H19F3N2O
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C
    선적

    Room temperature in continental US; may vary elsewhere.
    보관
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    용액&용해도
    In Vitro: 

    DMSO : 100 mg/mL (237.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3785 mL 11.8926 mL 23.7852 mL
    5 mM 0.4757 mL 2.3785 mL 4.7570 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    순도&문서

    Purity: 99.94%

    SDS (252 KB)

    COA (252 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3785 mL 11.8926 mL 23.7852 mL 59.4629 mL
    5 mM 0.4757 mL 2.3785 mL 4.7570 mL 11.8926 mL
    10 mM 0.2379 mL 1.1893 mL 2.3785 mL 5.9463 mL
    15 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
    20 mM 0.1189 mL 0.5946 mL 1.1893 mL 2.9731 mL
    25 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3785 mL
    30 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
    40 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4866 mL
    50 mM 0.0476 mL 0.2379 mL 0.4757 mL 1.1893 mL
    60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
    80 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7433 mL
    100 mM 0.0238 mL 0.1189 mL 0.2379 mL 0.5946 mL
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    VT104 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    VT1042417718-25-1VT 104VT-104YAPYes-associated proteinTEAD1TEAD3palmitoylationcancarInhibitorinhibitorinhibit

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    상품명:
    VT104
    Cat. No.:
    HY-134956
    수량:
    MCE Japan Authorized Agent:

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    SAFETY DATA SHEET (SDS)

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