α-Amylase/α-Glucosidase-IN-10

製品番号: HY-162373: Data Sheet 取扱説明書
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α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC₅₀: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

α-Amylase/α-Glucosidase-IN-10 構造式

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
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製品説明	α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC₅₀: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects^[1].
IC₅₀ & Target	IC50: 30.39 μM (α-Amylase); 65.1 μM (α-Glucosidase)[1]
分子量	622.15
分子式	C₃₃H₄₀ClN₅O₅
SMILES	O=C(/C1=N\NC(COC2=C(C)C=CC=C2C[C@H]3ON([C@]4(C[C@H](C)CC[C@H]4C(C)C)N(C)C5=O)[C@@]5([H])C3)=O)NC6=C1C=CC(Cl)=C6
輸送条件	Room temperature in continental US; may vary elsewhere.
保管条件	Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション	データシート (272 KB) 取扱説明書 (2659 KB)
参考文献	[1]. Ghannay S, et al. Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches. Heliyon. 2024 Feb 11;10(4):e25911. [Content Brief]