β-Aminoarteether maleate
β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases.
For research use only. We do not sell to patients.
- CAS No.: 133162-25-1
- Formula: C21H33NO9
- Molecular Weight:443.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CD4+ve Th | IC50 |
1.05 μM
Compound: 3; SM934
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Inhibition of human CD4+ve Th cell proliferation
Inhibition of human CD4+ve Th cell proliferation
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[PMID: 32631539] |
β-Aminoarteether (SM934;10 μM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation[1].
In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NZB/W F1 mice (Six and half months old)[1]
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Dosage:1 mg/kg, 3 mg/kg, and 10 mg/kg
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Administration:Oral administration; daliy; for 3 months
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Result:Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice.
Chemical Information
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CAS No. 133162-25-1
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Molecular Weight 443.49
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Formula C21H33NO9
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SMILES
C[C@@H]1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(OO4)[C@@](O[C@@H]1OCCN)([H])O[C@@]34C.O=C(O)/C=C\C(O)=O
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Synonyms
SM934
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Li-Fei Hou, et al. SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell development. PLoS One. 2012;7(2):e32424. [Content Brief]
[2]. Yang FM, Fan D, Yang XQ, et al. The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling. Acta Pharmacol Sin. 2021;42(4):593-603. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Aminoarteether maleate Related Classifications
HY-137553A Related Classifications
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