β-Aminoarteether
Based on 1 Customer Validation
β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.29%
- CAS. Nr.: 133162-24-0
- Formel: C17H29NO5
- Molecular Weight:327.42
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-B0094
ArtemisininParasite Inhibitor -
HY-N0193
ArtesunateVirus Protease Inhibitor -
HY-N0176
DihydroartemisininAntimalarial Agent -
HY-N0402
ArtemetherParasite Inhibitor -
HY-N0139
TroxerutinNOD-like Receptor (NLR) Inhibitor -
HY-P5544
M-TriDAPNOD1/2 Agoist -
HY-153261
NLRP3-IN-17NLRP3 Inflammasome Inhibitor -
HY-151252
NIC-0102Proteasome Inhibitor -
HY-163159
NP3-562NLRP3 Inhibitor -
HY-117432
JC-171NLRP3 Inhibitor -
HY-120048
NBC19NLRP3 inflammasome Inhibitor -
HY-153554
NLRP3-IN-18NLRP3 Inhibitor
Biologische Aktivität
Beschreibung
In Vitro
β-Aminoarteether (SM934;10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation[1].
In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NZB/W F1 mice (Six and half months old)[1]
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Dosage:1 mg/kg, 3 mg/kg, and 10 mg/kg
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Administration:Oral administration; daliy; for 3 months
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Result:Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 133162-24-0
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Appearance Oil
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Molecular Weight 327.42
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Formel C17H29NO5
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Color Light yellow to yellow
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SMILES
C[C@@H]1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(OO4)[C@@](O[C@@H]1OCCN)([H])O[C@@]34C
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Synonyms
SM934 free base
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (152.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.64 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Li-Fei Hou, et al. SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell development. PLoS One. 2012;7(2):e32424. [Content Brief]
[2]. Yang FM, Fan D, Yang XQ, et al. The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling. Acta Pharmacol Sin. 2021;42(4):593-603. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0542 mL | 15.2709 mL | 30.5418 mL | 76.3545 mL |
| 5 mM | 0.6108 mL | 3.0542 mL | 6.1084 mL | 15.2709 mL | |
| 10 mM | 0.3054 mL | 1.5271 mL | 3.0542 mL | 7.6355 mL | |
| 15 mM | 0.2036 mL | 1.0181 mL | 2.0361 mL | 5.0903 mL | |
| 20 mM | 0.1527 mL | 0.7635 mL | 1.5271 mL | 3.8177 mL | |
| 25 mM | 0.1222 mL | 0.6108 mL | 1.2217 mL | 3.0542 mL | |
| 30 mM | 0.1018 mL | 0.5090 mL | 1.0181 mL | 2.5452 mL | |
| 40 mM | 0.0764 mL | 0.3818 mL | 0.7635 mL | 1.9089 mL | |
| 50 mM | 0.0611 mL | 0.3054 mL | 0.6108 mL | 1.5271 mL | |
| 60 mM | 0.0509 mL | 0.2545 mL | 0.5090 mL | 1.2726 mL | |
| 80 mM | 0.0382 mL | 0.1909 mL | 0.3818 mL | 0.9544 mL | |
| 100 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.7635 mL |
β-Aminoarteether Related Classifications
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