β-Glucocerebrosidase modulator 1

Cat. No.: HY-163779 Purity: 99.01%: Data Sheet
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Handling Instructions
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β-Glucocerebrosidase modulator 1 (Compound 28) is an allosteric modulator for β-Glucocerebrosidase with an EC₅₀ of 9.0 μM and a K_d of 0.050 μM.

For research use only. We do not sell to patients.

β-Glucocerebrosidase modulator 1 Chemical Structure

CAS No. : 3080715-77-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

β-Glucocerebrosidase modulator 1 (Compound 28) is an allosteric modulator for β-Glucocerebrosidase with an EC₅₀ of 9.0 μM and a K_d of 0.050 μM^[1].

Molecular Weight

366.43

Formula

C₁₈H₂₀F₂N₂O₂S

CAS No.

3080715-77-8

Appearance

Oil

Color

Light yellow to yellow

SMILES

CN(C[C@@H](C1=CC(C(C)=C)=CC=C1)N)S(C2=CC(F)=CC(F)=C2)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7290 mL	13.6452 mL	27.2903 mL
5 mM	0.5458 mL	2.7290 mL	5.4581 mL
10 mM	0.2729 mL	1.3645 mL	2.7290 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.01%

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Data Sheet (269 KB) SDS (252 KB)

COA (248 KB) HNMR (129 KB) RP-HPLC (137 KB) LCMS (386 KB)

Handling Instructions (2659 KB)

References

[1]. Palmer N, et al., Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase. J Med Chem. 2024 Jul 11;67(13):11168-11181. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7290 mL	13.6452 mL	27.2903 mL	68.2259 mL
	5 mM	0.5458 mL	2.7290 mL	5.4581 mL	13.6452 mL
	10 mM	0.2729 mL	1.3645 mL	2.7290 mL	6.8226 mL
	15 mM	0.1819 mL	0.9097 mL	1.8194 mL	4.5484 mL
	20 mM	0.1365 mL	0.6823 mL	1.3645 mL	3.4113 mL
	25 mM	0.1092 mL	0.5458 mL	1.0916 mL	2.7290 mL
	30 mM	0.0910 mL	0.4548 mL	0.9097 mL	2.2742 mL
	40 mM	0.0682 mL	0.3411 mL	0.6823 mL	1.7056 mL
	50 mM	0.0546 mL	0.2729 mL	0.5458 mL	1.3645 mL
	60 mM	0.0455 mL	0.2274 mL	0.4548 mL	1.1371 mL
	80 mM	0.0341 mL	0.1706 mL	0.3411 mL	0.8528 mL
	100 mM	0.0273 mL	0.1365 mL	0.2729 mL	0.6823 mL