12-O-Tiglylphorbol-13-isobutyrate

製品番号: HY-107227: Data Sheet 取扱説明書
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12-O-Tiglylphorbol-13-isobutyrate is a phorbol diester constituent of Croton tiglium L. seed oil (croton oil).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

12-O-Tiglylphorbol-13-isobutyrate 構造式

CAS 番号 : 92214-54-5

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
参考文献
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製品説明

12-O-Tiglylphorbol-13-isobutyrate is a phorbol diester constituent of Croton tiglium L. seed oil (croton oil)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	32 μM Compound: 7	Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
DU-145	IC₅₀	1.1 μM Compound: 7	Cytotoxicity against human DU145 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human DU145 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
HEK-293T	IC₅₀	171.4 μM Compound: 7	Cytotoxicity against human 293T cells after 44 hrs by MTT assay Cytotoxicity against human 293T cells after 44 hrs by MTT assay	[PMID: 25819096]
HL-60	IC₅₀	1.2 μM Compound: 7	Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
HeLa	IC₅₀	9.2 μM Compound: 7	Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
K562	IC₅₀	4.4 μM Compound: 7	Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
MCF7	IC₅₀	> 50 μM Compound: 7	Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
MOLT-4	IC₅₀	1.1 μM Compound: 7	Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
NCI-H1975	IC₅₀	10 μM Compound: 7	Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
SGC-7901	IC₅₀	43 μM Compound: 7	Cytotoxicity against human SGC7901 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human SGC7901 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
SNU-387	IC₅₀	> 10 μM Compound: 9	Cytotoxicity against human SNU387 cells after 48 hrs by MTT assay Cytotoxicity against human SNU387 cells after 48 hrs by MTT assay	[PMID: 23701597]
U-937	IC₅₀	5.5 μM Compound: 7	Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]

分子量

516.62

分子式

C₂₉H₄₀O₈

CAS 番号

92214-54-5

SMILES

O=C(C(C)C)O[C@@]1([C@@H]([C@H]2C)OC(/C(C)=C/C)=O)[C@@]([C@@](C=C(C3)CO)([H])[C@]2([C@@](C=C4C)([H])[C@]3(C4=O)O)O)([H])C(C)1C

Structure Classification

Others

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Erdelmeier CA, et al. Phorbol diester constituents of croton oil: separation by two-dimensional TLC and rapid purification utilizing reversed-phase overpressure layer chromatography (RP-OPLC). Planta Med. 1988;54(1):71-75. [Content Brief]