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Cat. No.: HY-107227

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12-O-Tiglylphorbol-13-isobutyrate

12-O-Tiglylphorbol-13-isobutyrate is a phorbol diester constituent of Croton tiglium L. seed oil (croton oil).

For research use only. We do not sell to patients.

CAS No.: 92214-54-5
Formula: C₂₉H₄₀O₈
Molecular Weight:516.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

12-O-Tiglylphorbol-13-isobutyrate Chemical Structure

CAS No.: 92214-54-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

12-O-Tiglylphorbol-13-isobutyrate is a phorbol diester constituent of Croton tiglium L. seed oil (croton oil)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	32 μM Compound: 7	Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
DU-145	IC₅₀	1.1 μM Compound: 7	Cytotoxicity against human DU145 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human DU145 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
HEK-293T	IC₅₀	171.4 μM Compound: 7	Cytotoxicity against human 293T cells after 44 hrs by MTT assay Cytotoxicity against human 293T cells after 44 hrs by MTT assay	[PMID: 25819096]
HeLa	IC₅₀	9.2 μM Compound: 7	Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
HL-60	IC₅₀	1.2 μM Compound: 7	Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
K562	IC₅₀	4.4 μM Compound: 7	Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
MCF7	IC₅₀	>50 μM Compound: 7	Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
MOLT-4	IC₅₀	1.1 μM Compound: 7	Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
NCI-H1975	IC₅₀	10 μM Compound: 7	Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
SGC-7901	IC₅₀	43 μM Compound: 7	Cytotoxicity against human SGC7901 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human SGC7901 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]
SNU-387	IC₅₀	>10 μM Compound: 9	Cytotoxicity against human SNU387 cells after 48 hrs by MTT assay Cytotoxicity against human SNU387 cells after 48 hrs by MTT assay	[PMID: 23701597]
U-937	IC₅₀	5.5 μM Compound: 7	Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 25819096]

Chemical Information

CAS No. 92214-54-5
Molecular Weight 516.62
Formula C₂₉H₄₀O₈
SMILES

O=C(C(C)C)O[C@@]1([C@@H]([C@H]2C)OC(/C(C)=C/C)=O)[C@@]([C@@](C=C(C3)CO)([H])[C@]2([C@@](C=C4C)([H])[C@]3(C4=O)O)O)([H])C(C)1C
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Erdelmeier CA, et al. Phorbol diester constituents of croton oil: separation by two-dimensional TLC and rapid purification utilizing reversed-phase overpressure layer chromatography (RP-OPLC). Planta Med. 1988;54(1):71-75. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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