18β-Glycyrrhetinic acid-d3
18β-Glycyrrhetinic acid-d3 is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
For research use only. We do not sell to patients.
- Purity: 98.92%
- Formula: C30H43D3O4
- Molecular Weight:473.70
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 471-53-4
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Appearance Solid
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Molecular Weight 473.70
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Formula C30H43D3O4
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Color White to off-white
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SMILES
C[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O)=O)C)C)=O)([H])[C@@]5([C@@](C(C)([C@@](C([2H])([2H])C5)([2H])O)C)([H])CC1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (263.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Huang RY, et al. 18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer. PLoS One. 2014 Apr 2;9(4):e93690. [Content Brief]
[3]. Zhou J, et al. 18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination. Sci Rep. 2015 Sep 2;5:13713. [Content Brief]
[4]. Yang G, et al. Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats. Evid Based Complement Alternat Med. 2017;2017:3470320. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1110 mL | 10.5552 mL | 21.1104 mL | 52.7760 mL |
| 5 mM | 0.4222 mL | 2.1110 mL | 4.2221 mL | 10.5552 mL | |
| 10 mM | 0.2111 mL | 1.0555 mL | 2.1110 mL | 5.2776 mL | |
| 15 mM | 0.1407 mL | 0.7037 mL | 1.4074 mL | 3.5184 mL | |
| 20 mM | 0.1056 mL | 0.5278 mL | 1.0555 mL | 2.6388 mL | |
| 25 mM | 0.0844 mL | 0.4222 mL | 0.8444 mL | 2.1110 mL | |
| 30 mM | 0.0704 mL | 0.3518 mL | 0.7037 mL | 1.7592 mL | |
| 40 mM | 0.0528 mL | 0.2639 mL | 0.5278 mL | 1.3194 mL | |
| 50 mM | 0.0422 mL | 0.2111 mL | 0.4222 mL | 1.0555 mL | |
| 60 mM | 0.0352 mL | 0.1759 mL | 0.3518 mL | 0.8796 mL | |
| 80 mM | 0.0264 mL | 0.1319 mL | 0.2639 mL | 0.6597 mL | |
| 100 mM | 0.0211 mL | 0.1056 mL | 0.2111 mL | 0.5278 mL |
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