2,2-Dihydroxy-1-phenylethan-1-one (Synonyms: Phenylglyoxal hydrate)

Name: 2,2-Dihydroxy-1-phenylethan-1-one
Brand: MedChemExpress
SKU: HY-128407
Rating: 4.5 (0 reviews)

Cat. No.: HY-128407 Pureza: 97.0%: Ficha de datos
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2,2-Dihydroxy-1-phenylethan-1-one (Phenylglyoxal hydrate) is a phenylglyoxal-based, antioxidant drug synthesis intermediate. 2,2-Dihydroxy-1-phenylethan-1-one serves as a starting material for the synthesis of aromatic amines or aliphatic amines. It can be used to synthesize polysubstituted pyrrolo[3,2-c]pyridin-4-one derivatives, and also acts as a key structural unit in the microwave-assisted cascade synthesis of substituted 2-methyl-7-aryl-6H-thiazoloindole compounds.

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2,2-Dihydroxy-1-phenylethan-1-one Estructura química

No. CAS : 1075-06-5

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
25 g	En stock	Estimated Time of Arrival: December 31
50 g	Obtener un presupuesto

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Descripciòn

In Vitro

2,2-dihydroxy-1-phenylethan-1-one (0.5 mmol; 30 min) serves as a building block for catalyst-free, microwave-assisted aqueous three-component tandem reactions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

152.15

Fòrmula

C₈H₈O₃

No. CAS

1075-06-5

Appearance

Solid

Color

Colorless to light pink

SMILES

OC(O)C(C1=CC=CC=C1)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 200 mg/mL (1314.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (164.31 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5725 mL	32.8623 mL	65.7246 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (13.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (13.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (13.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 20 mg/mL (131.45 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 97.0%

Select Batch:

Ficha de datos (274 KB) SDS (394 KB)

COA (249 KB) HNMR (109 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Li C, et al. A multicomponent two-step strategy for the synthesis of polysubstituted pyrrolo [3, 2-c] pyridin-4-ones using a solid acid as a recyclable catalyst[J]. Green Chemistry, 2019, 21(11): 3109-3115.

[2]. Wang J, et al. Cascade Construction of Diverse Thiazoloindoles via the Generation of New Indole Skeletons Under Microwave Irradiation[J]. Asian Journal of Organic Chemistry, 2026, 15(3): e70361.

[3]. Tania Kundu, et al. Expeditious and eco-friendly synthesis of new multifunctionalized pyrrole derivatives and evaluation of their antioxidant property. Bioorg Chem. 2020 May;98:103734. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	6.5725 mL	32.8623 mL	65.7246 mL	164.3115 mL
	5 mM	1.3145 mL	6.5725 mL	13.1449 mL	32.8623 mL
	10 mM	0.6572 mL	3.2862 mL	6.5725 mL	16.4312 mL
	15 mM	0.4382 mL	2.1908 mL	4.3816 mL	10.9541 mL
	20 mM	0.3286 mL	1.6431 mL	3.2862 mL	8.2156 mL
	25 mM	0.2629 mL	1.3145 mL	2.6290 mL	6.5725 mL
	30 mM	0.2191 mL	1.0954 mL	2.1908 mL	5.4771 mL
	40 mM	0.1643 mL	0.8216 mL	1.6431 mL	4.1078 mL
	50 mM	0.1314 mL	0.6572 mL	1.3145 mL	3.2862 mL
	60 mM	0.1095 mL	0.5477 mL	1.0954 mL	2.7385 mL
	80 mM	0.0822 mL	0.4108 mL	0.8216 mL	2.0539 mL
	100 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6431 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

2,2-Dihydroxy-1-phenylethan-1-one Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,2-Dihydroxy-1-phenylethan-1-one1075-06-5PhenylglyoxalDrug IntermediateDrug Iintermediatesubstituted 2-methyl-7-aryl-6H-thiazoloindolespolysubstituted pyrrolo[3,2-c]pyridin-4-one derivatives5-(2-methyl-7-phenyl-6H-thiazolo[4,5-e]indol-8-yl)pyrimidine-2,4,6(1H,3H,5H)-trionethree-component cascade reactionmulticomponent reactionsmicrowave-assisted cascade synthesisphenylglyoxal5-amino-3-(2-oxo-2-phenylethyl)-2,3-dihydro-1H-pyrido[2,3-d]pyrimidine-2,4-dioneInhibitorinhibitorinhibit

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2,2-Dihydroxy-1-phenylethan-1-one (Synonyms: Phenylglyoxal hydrate)

Revisión del cliente

2,2-Dihydroxy-1-phenylethan-1-one Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

2,2-Dihydroxy-1-phenylethan-1-one Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

2,2-Dihydroxy-1-phenylethan-1-one Related Classifications

Keywords:

Productos vistos recientemente:

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SAFETY DATA SHEET (SDS)

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