2-Amino-2′-C-methyladenosine
2-Amino-2′-C-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- CAS No.: 640725-73-1
- Formula: C11H16N6O4
- Molecular Weight:296.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | CC50 |
>100 μM
Compound: 7
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Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 5 days by Cell-titer 96 aqueous one solution cell proliferation assay
Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 5 days by Cell-titer 96 aqueous one solution cell proliferation assay
|
[PMID: 25849312] |
| HepG2 | CC50 |
>50 μM
Compound: 7
|
Mitochondrial toxicity in human HepG2 cells assessed as effect on mitochondrial cytochrome c oxidase subunit 2 DNA level incubated for 14 days by real-time PCR method
Mitochondrial toxicity in human HepG2 cells assessed as effect on mitochondrial cytochrome c oxidase subunit 2 DNA level incubated for 14 days by real-time PCR method
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[PMID: 25849312] |
| HepG2 | CC50 |
>50 μM
Compound: 7
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Mitochondrial toxicity in human HepG2 cells assessed as effect on nuclear beta-actin DNA level incubated for 14 days by real-time PCR method
Mitochondrial toxicity in human HepG2 cells assessed as effect on nuclear beta-actin DNA level incubated for 14 days by real-time PCR method
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[PMID: 25849312] |
| Huh-7 | CC50 |
>33 μM
Compound: 7
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Cytotoxicity against human HuH7 cells assessed as reduction in rRNA levels incubated for 5 days by RT-PCR assay
Cytotoxicity against human HuH7 cells assessed as reduction in rRNA levels incubated for 5 days by RT-PCR assay
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[PMID: 25849312] |
| Huh-7 | EC50 |
5.4 μM
Compound: 7
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Antiviral activity against HCV infected in human HuH7 cells assessed as reduction in replicon RNA levels incubated for 5 days by RT-PCR assay
Antiviral activity against HCV infected in human HuH7 cells assessed as reduction in replicon RNA levels incubated for 5 days by RT-PCR assay
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[PMID: 25849312] |
| PBMC | CC50 |
>100 μM
Compound: 7
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Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 5 days by Cell-titer 96 aqueous one solution cell proliferation assay
Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 5 days by Cell-titer 96 aqueous one solution cell proliferation assay
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[PMID: 25849312] |
| Vero | CC50 |
>100 μM
Compound: 7
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 5 days by Cell-titer 96 aqueous one solution cell proliferation assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 5 days by Cell-titer 96 aqueous one solution cell proliferation assay
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[PMID: 25849312] |
Chemical Information
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CAS No. 640725-73-1
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Molecular Weight 296.28
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Formula C11H16N6O4
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SMILES
OC[C@@H]1[C@@H](O)[C@@](C)(O)[C@H](N2C3=NC(N)=NC(N)=C3N=C2)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Amino-2′-C-methyladenosine Related Classifications
HY-152707 Related Classifications
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