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Cat. No.: HY-147182

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3,6-Diamino-9(10H)-acridone

Name: 3,6-Diamino-9(10H)-acridone
Brand: MedChemExpress
SKU: HY-147182
Price: 214.00 USD
Availability: InStock
Rating: 5 (1 reviews)

3,6-Diamino-9(10H)-acridone is a topoisomerase inhibitor.

For research use only. We do not sell to patients.

CAS No.: 42832-87-1
Formula: C₁₃H₁₁N₃O
Molecular Weight:225.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

3,6-Diamino-9(10H)-acridone Chemical Structure

CAS No.: 42832-87-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

3,6-Diamino-9(10H)-acridone is a topoisomerase inhibitor^[1].

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	37 μM Compound: 22	Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs	[PMID: 9371240]
CH1	IC₅₀	>100 μM Compound: 22	Cytotoxic potency required to inhibit CH1 cell growth by 50% Cytotoxic potency required to inhibit CH1 cell growth by 50%	[PMID: 9371240]
L1210	IC₅₀	35 μM Compound: 22	Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs	[PMID: 9371240]
SK-OV-3	IC₅₀	>100 μM Compound: 22	Cytotoxic potency required to inhibit SKOV-3 cell growth 50% Cytotoxic potency required to inhibit SKOV-3 cell growth 50%	[PMID: 9371240]

Chemical Information

CAS No. 42832-87-1
Molecular Weight 225.25
Formula C₁₃H₁₁N₃O
SMILES

O=C1C2=C(C=C(N)C=C2)NC3=CC(N)=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nunhart P, et al. Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity. Bioorg Chem. 2020 Jan;94:103393. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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