4-(Chloromethyl)-7-hydroxycoumarin

製品番号: HY-76779 純度: 98.01%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

4-(Chloromethyl)-7-hydroxycoumarin 構造式

CAS 番号 : 25392-41-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	在庫あり	Estimated Time of Arrival: December 31
Solid
100 mg	$30	在庫あり	Estimated Time of Arrival: December 31
250 mg	$54	在庫あり	Estimated Time of Arrival: December 31
500 mg		お問い合わせ
1 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

分子量

210.62

分子式

C₁₀H₇ClO₃

CAS 番号

25392-41-0

Appearance

Solid

Color

Off-white to pink

SMILES

O=C1OC(C=C2O)=C(C=C2)C(CCl)=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (474.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7480 mL	23.7399 mL	47.4798 mL
5 mM	0.9496 mL	4.7480 mL	9.4960 mL
10 mM	0.4748 mL	2.3740 mL	4.7480 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.01%

Select Batch:

データシート (273 KB) SDS (476 KB)

COA (249 KB) HNMR (117 KB) RP-HPLC (268 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783.

[2]. Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19):5892-5896.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7480 mL	23.7399 mL	47.4798 mL	118.6994 mL
	5 mM	0.9496 mL	4.7480 mL	9.4960 mL	23.7399 mL
	10 mM	0.4748 mL	2.3740 mL	4.7480 mL	11.8699 mL
	15 mM	0.3165 mL	1.5827 mL	3.1653 mL	7.9133 mL
	20 mM	0.2374 mL	1.1870 mL	2.3740 mL	5.9350 mL
	25 mM	0.1899 mL	0.9496 mL	1.8992 mL	4.7480 mL
	30 mM	0.1583 mL	0.7913 mL	1.5827 mL	3.9566 mL
	40 mM	0.1187 mL	0.5935 mL	1.1870 mL	2.9675 mL
	50 mM	0.0950 mL	0.4748 mL	0.9496 mL	2.3740 mL
	60 mM	0.0791 mL	0.3957 mL	0.7913 mL	1.9783 mL
	80 mM	0.0593 mL	0.2967 mL	0.5935 mL	1.4837 mL
	100 mM	0.0475 mL	0.2374 mL	0.4748 mL	1.1870 mL