1. PROTAC
  2. PROTAC Linker
  3. 5-(Biotinamido)pentylamine

5-(Biotinamido)pentylamine 

Cat. No.: HY-W076543 Purity: 99.40%
Handling Instructions

5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

5-(Biotinamido)pentylamine Chemical Structure

5-(Biotinamido)pentylamine Chemical Structure

CAS No. : 115416-38-1

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100 mg USD 960 In-stock
Estimated Time of Arrival: December 31
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Description

5-Biotinamidopentylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

328.47

Formula

C₁₅H₂₈N₄O₂S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (304.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0444 mL 15.2221 mL 30.4442 mL
5 mM 0.6089 mL 3.0444 mL 6.0888 mL
10 mM 0.3044 mL 1.5222 mL 3.0444 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
5-(Biotinamido)pentylamine
Cat. No.:
HY-W076543
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