5-Chlorouracil  (Synonyms: Fluorouracil impurity)

5-Chlorouracil (Fluorouracil Impurity) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic. Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are incre ased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue. References

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

146.53

C₄H₃ClN₂O₂

1820-81-1

Solid

White to off-white

O=C1NC(C(Cl)=CN1)=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)