1. PROTAC
  2. PROTAC Linker
  3. 7-O-(Cbz-N-amido-PEG4)-paclitaxel

7-O-(Cbz-N-amido-PEG4)-paclitaxel 

Cat. No.: HY-141148
Handling Instructions

7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

7-O-(Cbz-N-amido-PEG4)-paclitaxel Chemical Structure

7-O-(Cbz-N-amido-PEG4)-paclitaxel Chemical Structure

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Description

7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1235.33

Formula

C₆₆H₇₈N₂O₂₁

SMILES

CC1=C([[email protected]@H](OC(C)=O)C([[email protected]@]2(C)C([[email protected]@](CO3)(OC(C)=O)[[email protected]]3C[[email protected]@H]2OC(CCOCCOCCOCCOCCNC(OCC4=CC=CC=C4)=O)=O)[[email protected]@H]5OC(C6=CC=CC=C6)=O)=O)C(C)(C)[[email protected]@]5(O)C[[email protected]@H]1OC([[email protected]](O)[[email protected]@H](NC(C7=CC=CC=C7)=O)C8=CC=CC=C8)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

7-O-(Cbz-N-amido-PEG4)-paclitaxelPROTAC LinkerInhibitorinhibitorinhibit

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Product Name:
7-O-(Cbz-N-amido-PEG4)-paclitaxel
Cat. No.:
HY-141148
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