7-O-(Cbz-N-amido-PEG4)-paclitaxel
7-O-(Cbz-N-amido-PEG4)-paclitaxel is a PEG-class Drug-linker conjugates for ADC, containing a paclitaxel moiety and a amino group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. 7-O-(Cbz-N-amido-PEG4)-paclitaxel can be used in the synthesis of Antibody-Drug Conjugates (ADCs).
For research use only. We do not sell to patients.
- Formula: C66H78N2O21
- Molecular Weight:1235.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Description
IC50 & Target
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PEGs |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1235.33
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Formula C66H78N2O21
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SMILES
CC1=C([C@@H](OC(C)=O)C([C@@]2(C)C([C@@](CO3)(OC(C)=O)[C@H]3C[C@@H]2OC(CCOCCOCCOCCOCCNC(OCC4=CC=CC=C4)=O)=O)[C@@H]5OC(C6=CC=CC=C6)=O)=O)C(C)(C)[C@@]5(O)C[C@@H]1OC([C@H](O)[C@@H](NC(C7=CC=CC=C7)=O)C8=CC=CC=C8)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7-O-(Cbz-N-amido-PEG4)-paclitaxel Related Classifications
HY-141148 Related Classifications
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