1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Estramustine phosphate sodium

Estramustine phosphate sodium 

製品番号: HY-13627 純度: 99.84%
取扱説明書

Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium induces prostate cancer cells apoptosis and can be used for prostate cancer research.

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Estramustine phosphate sodium 構造式

Estramustine phosphate sodium 構造式

CAS 番号 : 52205-73-9

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in Water USD 79 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 72 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 119 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 168 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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製品説明

Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium induces prostate cancer cells apoptosis and can be used for prostate cancer research[1][2].

体外実験

Estramustine phosphate sodium (1 µg/mL) treatment suppressed PC3 cell growth[2].
Estramustine phosphate sodium (2 µg/mL) treatment significantly elevates phosphatidylserine eversion amount on PC3 cells. Estramustine phosphate sodium induces PC3 cell apoptosis[2].
Estramustine phosphate sodium (2 µg/mL) treatment decreases MiR-31 level. Estramustine phosphate odium induces s prostate cancer cell line PC3 apoptosis through reducing miR-31[2].
Estramustine phosphate sodium, a unique antitumour agent, is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone[1].
Estrone and estradiol, products of the metabolism of Estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels similar to those achieved after surgical castration[1].

体内実験

Estramustine phosphate sodium (4-12 mg/kg; intraperitoneal injection; daily; for 2 weeks) inhibits PAC120 tumor growth 53% by day 35[4].

Animal Model: Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors[3]
Dosage: 4 mg/kg, 12 mg/kg
Administration: Intraperitoneal injection; daily; for 2 weeks
Result: Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
分子量

564.35

分子式

C₂₃H₃₀Cl₂NNa₂O₆P

CAS 番号

52205-73-9

SMILES

O=C(N(CCCl)CCCl)OC1=CC2=C(C=C1)[[email protected]@]3([H])CC[[email protected]@]4(C)[[email protected]](CC[[email protected]@H]4OP(O[Na])(O[Na])=O)([H])[[email protected]]3([H])CC2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度
体外: 

H2O : 62.5 mg/mL (110.75 mM; Need ultrasonic)

H2O : 31.25 mg/mL (55.37 mM; Need ultrasonic)

DMSO : 5 mg/mL (8.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7720 mL 8.8598 mL 17.7195 mL
5 mM 0.3544 mL 1.7720 mL 3.5439 mL
10 mM 0.1772 mL 0.8860 mL 1.7720 mL
*Please refer to the solubility information to select the appropriate solvent.
参考文献

純度: 99.84%

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Keywords:

Estramustine phosphateMicrotubule/TubulinApoptosisAntimicrotubuleantitumourcaspase-3MiR-31mustard-17-βInhibitorinhibitorinhibit

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製品名:
Estramustine phosphate sodium
製品番号:
HY-13627
数量:
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