TA-316
Based on 1 Customer Validation
TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 1429321-13-0
- Formula: C28H25BrN4O5S2
- Molecular Weight:641.56
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC50 values of 0.3 and 0.65 nM, respectively[2].
TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers[2].
TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:UT-7/TPO and Ba/F3-HuMpl cells
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Concentration:0.01-1000 nM
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Incubation Time:4 days
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Result:Stimulated UT-7/TPO and Ba/F3-HuMpl cell proliferation.
Chemical Information
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CAS No. 1429321-13-0
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Appearance Solid
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Molecular Weight 641.56
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Formula C28H25BrN4O5S2
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(C(NCC2=CC=C(C(NCCO)=O)C=C2)=O)S1)N/N=C(C3=CSC(C4=CC=C(Br)C=C4)=C3O)\C
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Synonyms
Megakaryocytes/platelets inducing agent
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (77.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5587 mL | 7.7935 mL | 15.5870 mL | 38.9675 mL |
| 5 mM | 0.3117 mL | 1.5587 mL | 3.1174 mL | 7.7935 mL | |
| 10 mM | 0.1559 mL | 0.7794 mL | 1.5587 mL | 3.8968 mL | |
| 15 mM | 0.1039 mL | 0.5196 mL | 1.0391 mL | 2.5978 mL | |
| 20 mM | 0.0779 mL | 0.3897 mL | 0.7794 mL | 1.9484 mL | |
| 25 mM | 0.0623 mL | 0.3117 mL | 0.6235 mL | 1.5587 mL | |
| 30 mM | 0.0520 mL | 0.2598 mL | 0.5196 mL | 1.2989 mL | |
| 40 mM | 0.0390 mL | 0.1948 mL | 0.3897 mL | 0.9742 mL | |
| 50 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7794 mL | |
| 60 mM | 0.0260 mL | 0.1299 mL | 0.2598 mL | 0.6495 mL |
TA-316 Related Classifications
HY-112486 Related Classifications
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