2. Cell Cycle/DNA Damage
  3. Cyclin G-associated Kinase (GAK)
  4. TA-316

TA-316  (Synonyms: Megakaryocytes/platelets inducing agent)

Cat. No.: HY-112486 Purity: 98.19%
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TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells.

For research use only. We do not sell to patients.

TA-316 Chemical Structure

TA-316 Chemical Structure

CAS No. : 1429321-13-0

Size Price Stock Quantity
5 mg USD 850 In-stock
10 mg USD 1450 In-stock
25 mg USD 3000 In-stock
50 mg USD 4850 In-stock
100 mg USD 7600 In-stock
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Based on 1 publication(s) in Google Scholar

TA-316 Related Antibodies

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Description

TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells[1][2].

In Vitro

TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC50 values of 0.3 and 0.65 nM, respectively[2].
? TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers[2].
? TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TA-316 Related Antibodies

Cell Viability Assay[2]

Cell Line: UT-7/TPO and Ba/F3-HuMpl cells
Concentration: 0.01-1000 nM
Incubation Time: 4 days
Result: Stimulated UT-7/TPO and Ba/F3-HuMpl cell proliferation.
Molecular Weight

641.56

Formula

C28H25BrN4O5S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=CC=C(C(NCC2=CC=C(C(NCCO)=O)C=C2)=O)S1)N/N=C(C3=CSC(C4=CC=C(Br)C=C4)=C3O)\C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (77.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5587 mL 7.7935 mL 15.5870 mL
5 mM 0.3117 mL 1.5587 mL 3.1174 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5587 mL 7.7935 mL 15.5870 mL 38.9675 mL
5 mM 0.3117 mL 1.5587 mL 3.1174 mL 7.7935 mL
10 mM 0.1559 mL 0.7794 mL 1.5587 mL 3.8968 mL
15 mM 0.1039 mL 0.5196 mL 1.0391 mL 2.5978 mL
20 mM 0.0779 mL 0.3897 mL 0.7794 mL 1.9484 mL
25 mM 0.0623 mL 0.3117 mL 0.6235 mL 1.5587 mL
30 mM 0.0520 mL 0.2598 mL 0.5196 mL 1.2989 mL
40 mM 0.0390 mL 0.1948 mL 0.3897 mL 0.9742 mL
50 mM 0.0312 mL 0.1559 mL 0.3117 mL 0.7794 mL
60 mM 0.0260 mL 0.1299 mL 0.2598 mL 0.6495 mL
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TA-316 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TA-3161429321-13-0Megakaryocytes/platelets inducing agentTA316TA 316Cyclin G-associated Kinase (GAK)Auxilin 2Inhibitorinhibitorinhibit

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