Aiphanes aculeata Willd
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Aiphanes aculeata Willd (1)
(±)-Aiphanol
Cat. No.: HY-152120
CAS No.: 578020-29-8
Synonyms: Aiphanol
- Formula: C25H24O8
- Molecular Weight: 452.45
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC50 = 1.9 μM) is particularly strong, while the effect on COX-2 (IC50= 9.9 μM) is relatively weak.(±)-Aiphanol effectively inhibits VEGFR2 (IC50=0.92 μM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active.
