(±)-Aiphanol
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC50 = 1.9 μM) is particularly strong, while the effect on COX-2 (IC50= 9.9 μM) is relatively weak.(±)-Aiphanol effectively inhibits VEGFR2 (IC50=0.92 μM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active.
For research use only. We do not sell to patients.
- CAS No.: 578020-29-8
- Formula: C25H24O8
- Molecular Weight:452.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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COX-1 1.9 μM (IC50) |
COX-2 9.9 μM (IC50) |
VEGFR2 0.92 μM (IC50) |
(±)-Aiphanol (7.5-30 μM; 6 h) dose-dependently inhibits VEGF-induced neovascularization in HUVECs. (±)-Aiphanol significantly reduces the levels of PGE2 and VEGF in HUVECs, and this effect is abolished after COX2 knockdown. (±)-Aiphanol is more effective than Celecoxib (HY-14398) in inhibiting VEGF-induced tubular structure formation in HUVECs[2].
(±)-Aiphanol (7.5-30 μM; 6h) significantly inhibits microvascular growth in the CAM assay, with an effect comparable to Bevacizumab (HY-P9906)[2].
(±)-Aiphanol inhibits the activities of VEGFR3/FLT4, VEGFR2/KDR, and VEGFR1/FLT1, and also moderately or weakly inhibits certain kinases in the PI3K-AKT and MAPK pathways[2].
(±)-Aiphanol (30 μM; 24 h) inhibits the proliferation of HUVECs and induces cell apoptosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVECs
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Concentration:30 μM
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Incubation Time:24 h
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Result:Did not cause significant changes in cell cycle distribution but significantly increased apoptosis. Elevated the expression of P53 and BAX proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MC38 syngeneic mouse model[2]
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Dosage:30 mg/kg
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Administration:p.o.; single dose
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Result:Increased apoptosis in tumor tissues and reduced the phosphorylation levels of VEGFR2, AKT, and ERK.
Significantly decreased the levels of vascular markers CD31 and factor VIII.
Lowered the levels of PGE2 in plasma and VEGF in tumor tissues.
Did not cause changes in body weight or the morphology of major organs.
Chemical Information
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CAS No. 578020-29-8
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Molecular Weight 452.45
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Formula C25H24O8
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SMILES
OC[C@@H]1[C@@H](C2=CC(OC)=C(C(OC)=C2)O)OC3=CC(/C=C/C4=CC(O)=CC(O)=C4)=CC=C3O1
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Synonyms
Aiphanol
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(±)-Aiphanol Related Classifications
HY-152120 Related Classifications
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