Others

MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images.

MQA-P is a multifunctional near-infrared (NIR) fluorescent probe that simultaneously detects ONOO^-, viscosity, and polarity within mitochondria. MQA-P exhibits significant response to ONOO^-, λ_em=645 nm; and NIR channel at λ_em>704 nm Medium is highly sensitive to viscosity/polarity. MQA-P possesses excited-state intramolecular charge transfer (ESICT) properties that are highly sensitive to polarity by designing the N,N-dimethylamino group as the electron donor and the quinoline cation unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images.

RPE65-IN-1(Compound 16e) is a potent RPE65 inhibitor, with an IC₅₀ value of 0.29 μM. which can be used in retinopathy-related research.

UCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC₅₀ of 1.4 μM and human K_a of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome.

2'-O-Methyl-5-methyl-U CEP is a uridine, can be used for synthesis nucleic acid.

FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.

Insulin-Transferrin-Selenium-Sodium Pyruvate (ITS-A) is a basal media supplement used to reduce the amount of fetal bovine serum (FBS) used to culture cells.

Glutathione-glycine-¹³C₂,¹⁵N (trifluoroacetate) is the ¹³C and ¹⁵N labeled Glutathione-glycine trifluoroacetate.

Choline-d₁₃ (sulfate) is the deuterium labeled Choline sulfate.

3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl-¹³C₅ is the ¹³C labeled 3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl.

Androsterone glucuronide-d₄ is the deuterium labeled Androsterone glucuronide.

4-Fluorobenzoyl-2,3,5,6-d₄ chloride is the deuterium labeled 4-Fluorobenzoyl chloride.

PXS-4787 is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively.

PXS-6302 is an irreversible lysyl oxidase inhibitor with IC₅₀s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.

Fmoc-DAP-N3 is a click chemistry reagent containing an azide group. Fmoc-DAP-N3 is a short, linear spacer molecule with Fmoc protected amino function. Fmoc-DAP-N3 can be used in click conjugation and amid bond formation either with small molecules or for bioconjugation with proteins and antibodies. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

H-D-Tyr(Propargyl)-OH is a click chemistry reagent containing an Azide. H-D-Tyr(Propargyl)-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

H-L-Lys(N3-Gly)-OH hydrochloride is a click chemistry containing an azide group, a lysine derivative. H-L-Lys(N3-Gly)-OH hydrochloride can be incorporated into proteins for click modifications. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

(R,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.

DiSulfo-Cy5 alkyne is a fluorescent dye can be used as a click chemistry reagent.

Cy3 methyltetrazine (TZ-Cy3) is a click chemistry reagent with methyltetrazine building blocks that is highly reactive towards cyclooctene. Cy3 methyltetrazine is also a tetrazine-modified fluorescent probe that can be used to analyze protein phosphorylation in solution and living cells.