1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

SB 277011A dihydrochloride 

Cat. No.: HY-10847A
Handling Instructions

SB 277011A dihydrochloride is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.

For research use only. We do not sell to patients.

SB 277011A dihydrochloride Chemical Structure

SB 277011A dihydrochloride Chemical Structure

CAS No. : 1226917-67-4

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Other Forms of SB 277011A dihydrochloride:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SB 277011A dihydrochloride is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.

IC50 & Target

pKi: 8.0 (D3 receptor), 6.0 (D2 receptor), <5.2 (5-HT1B receptor), 5.9 (5-HT1D receptor)[1]

In Vitro

SB 277011A dihydrochloride is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, and restores ≥100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively[1].

In Vivo

SB 277011A (SB 277011; 3 mg/kg, p.o.) completely reverses the effects of quinelorane in the nucleus accumbens, but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9551 mL 9.7754 mL 19.5507 mL
5 mM 0.3910 mL 1.9551 mL 3.9101 mL
10 mM 0.1955 mL 0.9775 mL 1.9551 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

511.49

Formula

C₂₈H₃₂Cl₂N₄O

CAS No.

1226917-67-4

SMILES

O=C(C1=CC=NC2=CC=CC=C12)N[[email protected]]3CC[[email protected]](CCN4CC5=C(C=C(C#N)C=C5)CC4)CC3.[H]Cl.[H]Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SB 277011A dihydrochloride
Cat. No.:
HY-10847A
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SB 277011A dihydrochloride

Cat. No.: HY-10847A