2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147952
    AChE-IN-20
    		Inhibitor
    AChE-IN-20 (compound M26) is a potent AChE inhibitor with IC50 value of 397.32 nM and with Ki value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC50 values of 84.14, 69.24 and 52.08 nM and with Ki values of 97.86, 76.23 and 57.93 nM, respectively.
    AChE-IN-20
  • HY-157982
    BChE-IN-28
    		Inhibitor
    BChE-IN-28 (compound 6J) is a selective butyrylcholinesterase (BChE) inhibitor with an IC50 of 8 nM and a Ki of 12.16 nM. BChE-IN-28 shows the lower inhibition against AChE, MAO-A and MAO-B.
    BChE-IN-28
  • HY-155713
    AChE-IN-34
    		Inhibitor
    AChE-IN-34 (compound 5l) is a potent and selective AChE inhibitor with an IC50 value of 3.98 µM with no significant inhibition against BChE. AChE-IN-34 inhibits AChE with a Ki of 0.044 μM in a mixed mode (Acetylthiocholine substrate; 0.1-1 mM).
    AChE-IN-34
  • HY-174464
    AChE/BChE-IN-28
    		Inhibitor
    AChE/BChE-IN-28 (Compound 5q) is a BChE inhibitor with an IC50 of 13.49 μM. AChE/BChE-IN-28 also exerts moderate inhibitory effect on AChE, with an IC50 of 35.23 μM. AChE/BChE-IN-28 can be used in the research of Alzheimer's disease.
    AChE/BChE-IN-28
  • HY-W750404
    (-)-Carvone-d4
    (-)-Carvone-d4 is the deuterium labeled (-)-Carvone (HY-W017423). (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae.
    (-)-Carvone-d<sub>4<sub>
  • HY-155621
    PD24
    		Inhibitor
    PD24 is an AChE and BuChE inhibitor (hAChE IC50: 1.72 μM; eeAChE IC50: 1.76 μM; eqBuChE IC50: 2.64 μM). PD24 also has antioxidant activity, and inhibits DPPH (IC50: 28.72 μM). PD24 can be used for research of Alzheimer’s disease.
    PD24
  • HY-B0916R
    Propoxur (Standard)
    		Inhibitor
    Propoxue (Standard) is the analytical standard of Propoxue (HY-B0916). This product is intended for research and analytical applications. Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests.
    Propoxur (Standard)
  • HY-183341
    sEH/AChE-IN-5
    sEH/AChE-IN-5 is a selective, orally active and brain-penetrant acetylcholinesterase (AChE) and soluble epoxide hydrolase (sEH) dual inhibitor with IC50 values of 1.7 nM and 0.7 nM. sEH/AChE-IN-5 mediates neuroprotection and anti-inflammation via reduced TNF-α, IL-1β, IL-6, iNOS. sEH/AChE-IN-5 improves Scopolamine (HY-N0296)-induced learning and memory deficits mice. sEH/AChE-IN-5 can be used for the research of Alzheimer's disease.
    sEH/AChE-IN-5
  • HY-N11962A
    2,3,9,10-Tetrahydroxyberberine bromide
    		Inhibitor
    2,3,9,10-Tetrahydroxyberberine bromide is an acetylcholinesterase AChE inhibitor (IC50=7.8 μM). 2,3,9,10-Tetrahydroxyberberine bromide exhibits DPPH free radical scavenging activity (IC50=43 μM) and is applicable to research related to Alzheimer's disease.
    2,3,9,10-Tetrahydroxyberberine bromide
  • HY-N18024
    Kaempferol-3-O-glu-rha-glu
    		Inhibitor
    Kaempferol-3-O-glu-rha-glu is an insecticide. Kaempferol-3-O-glu-rha-glu inhibits activities of the enzymes CarE, GSTs, MFO, and AChE. Kaempferol-3-O-glu-rha-glu exhibits cytotoxicity and disrupts mitochondrial membrane potential and increases ROS production. Kaempferol-3-O-glu-rha-glu can be used for the infection.
    Kaempferol-3-O-glu-rha-glu
  • HY-181445
    NSC 620023 TFA
    		Inhibitor
    NSC 620023 TFA is a highly selective butyrylcholinesterase (BChE) inhibitor with an IC50 of 32 nM. NSC 620023 TFA acts via π-stacking interactions with dual benzimidazole moieties and hydrophobic interactions within the BChE binding site. NSC 620023 TFA can be used for the research of alzheimer’s disease.
    NSC 620023 TFA
  • HY-RS00158
    ACHE Rat Pre-designed siRNA Set A
    		Inhibitor

    ACHE Rat Pre-designed siRNA Set A contains three designed siRNAs for ACHE gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ACHE Rat Pre-designed siRNA Set A
  • HY-158695
    Dual AChE-MAO B-IN-4
    		Inhibitor
    Dual AChE-MAO B-IN-4 (compound 7) is a dual AChE/MAO-B inhibitor, with IC50 values ​​of 261 nM and 15 nM, respectively. Dual AChE-MAO B-IN-4 protects against oxidative damage induced by H2O2 and 6-OHDA in SH-SY5Y cells. Dual AChE-MAO B-IN-4 can penetrate the central nervous system in a cell model that mimics the blood-brain barrier. Dual AChE-MAO B-IN-4 can be used in the study of neurological diseases such as Alzheimer's disease (AD).
    Dual AChE-MAO B-IN-4
  • HY-179711
    AChE/BChE-IN-32
    		Inhibitor
    AChE/BChE-IN-32 (Compound 4a) is an AChE and BChE inhibitor, with Ki values of 2.48 and 0.696 μM respectively. AChE/BChE-IN-32 inhibits Aβ aggregation and exhibits a strong ABTS•+ scavenging ability (TEAC = 2.40). AChE/BChE-IN-32 shows significant neuroprotective activity in glutamate and hydrogen peroxide-induced oxidative stress models. AChE/BChE-IN-32 can be used for the study of Alzheimer's disease.
    AChE/BChE-IN-32
  • HY-123887
    Manumycin B
    		Inhibitor
    Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC50 of 15 mM.
    Manumycin B
  • HY-N8547A
    (Rac)-Sclerone
    		Inhibitor
    (Rac)-Sclerone is a natural product, that can be isolated from the green husk of Carya illinoinensis. (Rac)-Sclerone shows appreciable inhibition of AChE, with an IC50 of 192.65 ± 10.12 μg/mL.
    (Rac)-Sclerone
  • HY-182254
    AChE/BChE-IN-35
    		Inhibitor
    AChE/BChE-IN-35, Tacrine (HY-111338) derivative, is a brain-penetrant dual AChE/BChE inhibitor with an Electric Eel AChE IC50 of 123.66 nM, human AChE IC50 of 122.34 nM, and equine BChE IC50 of 488.00 nM. AChE/BChE-IN-35 undergoes LAT1-mediated active transport across cell membranes. AChE/BChE-IN-35 exhibits enhanced brain exposure with slower brain tissue elimination. AChE/BChE-IN-35 can be used for the research of alzheimer's disease.
    AChE/BChE-IN-35
  • HY-N7265
    Epi-galantamine
    		Inhibitor
    Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45.7 μM.
    Epi-galantamine
  • HY-158696
    BChE/MAO-B-IN-1
    		Inhibitor
    BChE/MAO-B-IN-1 (compound 7) is a dual BChE/MAO-B inhibitor with IC50 values ​​of 375 nM and 20 nM, respectively. BChE/MAO-B-IN-1 protects against oxidative damage induced by H2O2 and 6-OHDA in SH-SY5Y cells. BChE/MAO-B-IN-1 can penetrate the central nervous system in a cell model that mimics the blood-brain barrier. BChE/MAO-B-IN-1 can be used in the study of neurological diseases such as Alzheimer's disease (AD).
    BChE/MAO-B-IN-1
  • HY-170938
    AChE-IN-82
    		Inhibitor
    AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2.
    AChE-IN-82
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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