AChE-IN-63
AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research.
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- No. CAS: 876685-78-8
- Fòrmula: C18H19N5O
- Peso molecular:321.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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hAChE 0.103 μM (IC50) |
hBCHE 10 μM (IC50) |
AChE-IN-63 (5-20 μM; 48 h) inhibits Aβ1-42 aggregation in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AChE-IN-63 (p.o.; 5-20 mg/kg; single dose) improves learning and memory in cognitive dysfunction mice in the Scopolamine (HY-N0296) Y-Maze Model and demonstrates good antioxidant properties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine Y-Maze Model [1]
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Dosage:5; 10 ;20 mg/kg
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Administration:p.o.; single dose
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Result:Showed significant improvement in spontaneous alternation behavior.
Reduced AChE and MDA levels and increased CAT levels.
Chemical Information
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No. CAS 876685-78-8
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Peso molecular 321.38
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Fòrmula C18H19N5O
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SMILES
C1(C2=NN=C(O2)CN3CCN(CC3)C4=CC=CC=N4)=CC=CC=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-63 Related Classifications
HY-158261 Related Classifications
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