876685-78-8
876685-78-8
Chemical Structure
AChE-IN-63
- CAS No.: 876685-78-8
- Formula:C18H19N5O
- Molecular Weight:321.38
InChIKey: BUNCKBADTDNSDP-UHFFFAOYSA-N
SMILES: C1(C2=NN=C(O2)CN3CCN(CC3)C4=CC=CC=N4)=CC=CC=C1
Biological Activity: AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research[1].
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AChE-IN-63 | AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research. | |||||||||||||||||||||
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References
Keywords
