129297-21-8
129297-21-8
Chemical Structure
SM 10888
- CAS No.: 129297-21-8
- Formula:C20H21FN2O7
- Molecular Weight:420.39
IUPAC Name: 8-fluoro-1,2,3,4-tetrahydro-2,4-methanoacridin-9-amine 2-hydroxypropane-1,2,3-tricarboxylate
InChIKey: ZCELBELLETVSEJ-UHFFFAOYSA-N
SMILES: NC1=C(C(F)=CC=C2)C2=NC3=C1CC4CC3C4.OC(C(O)=O)(CC(O)=O)CC(O)=O
Biological Activity: SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. SM 10888 can increase brain acetylcholine release. SM 10888 can be used for the research of neurological disease, such as Alzheimer's disease[1][2].
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SM 10888 | SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. SM 10888 can increase brain acetylcholine release. SM 10888 can be used for the research of neurological disease, such as Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Xu M, et al. Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease. Neurosci Lett. 1991 Feb 25;123(2):179-82. [Content Brief]
- [2]. Okazaki Y, et al. Effect of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice. Jpn J Pharmacol. 1990 Jun;53(2):211-20. [Content Brief]
Keywords
