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ADC Linkers Related Products (527)
Related Products (527)
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MC-GGFG-3-Methylenecyclobutyl
0 ImagesCat. No.: HY-181185CAS No.: 3109354-75-5MC-GGFG-3-Methylenecyclobutyl (compound L-7B) is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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6-Azidohexanoyl-Val-Cit-PAB-PNP
0 ImagesCat. No.: HY-151699CAS No.: 1613321-01-96-Azidohexanoyl-Val-Cit-PAB-PNP is a click chemistry reagent that can be used to synthesis It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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MeO-PEG750-alkyne
0 ImagesCat. No.: HY-151788MeO-PEG750-alkyne is a click chemistry reagent containing an alkyne group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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(2R,3S)-3-(tert-Butoxy)-2-4-ethyl-2,3-dioxopiperazine-1-carboxamidobutanoic acid
0 ImagesCat. No.: HY-W099352CAS No.: 79276-23-6(2R,3S)-3-(tert-Butoxy)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)butanoic acid is an ADC linker.
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(2S,3S)-H-Abu(3-N3)-OH hydrochloride
0 ImagesCat. No.: HY-151838CAS No.: 2737202-68-3(2S,3S)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent containing an azide group. (2S,3S)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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(Me)Tz-butanoic acid
0 ImagesCat. No.: HY-151730CAS No.: 1923268-81-8(Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles. (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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H-L-Tyr(2-azidoethyl)-OH
0 ImagesCat. No.: HY-151693ACAS No.: 1570523-47-5H-L-Tyr(2-azidoethyl)-OH is a unnatural Tyrosine derivative. H-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Boc-L-Lys(N3)-OH (CHA)
0 ImagesCat. No.: HY-W250992CAS No.: 2098497-30-2Boc-L-Lys(N3)-OH CHA is a click chemistry reagent containing an azide. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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DACN(Tos,Ns)
0 ImagesCat. No.: HY-151707CAS No.: 1797508-58-7DACN(Tos,Ns) is a click chemistry reagent containing an cyclic alkyne group.
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Propargyl-PEG4-CH2CO2-NHS
0 ImagesCat. No.: HY-140025CAS No.: 2144777-76-2Propargyl-PEG4-CH2CO2-NHS (compound P-7) is a PEG derivative containing a propargyl group and an NHS group. Propargyl-PEG4-CH2CO2-NHS is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-CH2CO2-NHS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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(2R,4R)-Boc-D-Pro(4-N3)-OH
0 ImagesCat. No.: HY-151848CAS No.: 650601-59-5(2R,4R)-Boc-D-Pro(4-N3)-OH is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Boc-Cystamine-Poc
0 ImagesCat. No.: HY-151767CAS No.: 2171512-56-2Boc-Cystamine-Poc (compound H4) is a click chemistry reagent with cystamine building block.
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8-Azido-octanoyl-OSu
0 ImagesCat. No.: HY-151823CAS No.: 2576471-56-08-Azido-octanoyl-OSu is a click chemistry reagent containing an azide group. Used as a building block to introduce 8-azidooctanoic acid (CAS 217180-76-2) fragment. This fragment is used for further modifications using Click-chemistry (CuAAC), as a protected aminogroup or is used in physico-chemical investigations. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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DACN(Tos2,6-OH)
0 ImagesCat. No.: HY-151754CAS No.: 2109751-74-6DACN(Tos2,6-OH) is a click chemistry reagent containing an Azide. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. The reactivity of an alkyne heavily depends on the electronic and steric characteristics of the substituents as well as structural strain. In comparison to nonbent acyclic alkynes, cyclononyne alkynes show remarkably high reactivity. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. In comparison to cyclooctynes, DACNs possess high thermal and chemical stability along with comparable click reactivity. DACN(Tos2,6-OH) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Boc-D-Aza-OH
0 ImagesCat. No.: HY-151784CAS No.: 225780-77-8Boc-D-Aza-OH is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Boc-PEG2-Val-Cit-PAB-OH
0 ImagesCat. No.: HY-W800624CAS No.: 2055024-55-8Boc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.
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Fmoc-L-Lys(N3-Aca-DIM)-OH
0 ImagesCat. No.: HY-151787CAS No.: 2408993-39-3Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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BCN-endo-PEG7-NH2
0 ImagesCat. No.: HY-156310CAS No.: 2143968-34-5BCN-endo-PEG7-NH2 is an ADC Linker containing 7 PEG units. BCN-endo-PEG7-NH2 contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
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Z-L-Dap(N3)-OH
0 ImagesCat. No.: HY-151849CAS No.: 684270-44-8Z-L-Dap(N3)-OH is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Alloc-Val-Ala-PAB-PNP
0 ImagesCat. No.: HY-W591336CAS No.: 1884578-27-1Alloc-Val-Ala-PAB-PNP is a cleavable ADC linker.
