6-Azidohexanoyl-Val-Cit-PAB-PNP
6-Azidohexanoyl-Val-Cit-PAB-PNP is a click chemistry reagent that can be used to synthesis It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- CAS No.: 1613321-01-9
- Formula: C24H38N8O5
- Molecular Weight:518.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-20336
Mc-Val-Cit-PABC-PNPADC Linker -
HY-15575
VcMMAEDrug-Linker Conjugate for ADC -
HY-12362
Val-cit-PAB-OHADC Linker -
HY-41189
Fmoc-Val-Cit-PAB-PNPADC Linker -
HY-78738
MC-Val-Cit-PABADC Linker -
HY-19318
Fmoc-Val-Cit-PABADC Linker -
HY-141142
Boc-Val-Cit-PAB-PNPADC Linker -
HY-140145
Mal-PEG4-Val-Cit-PAB-PNPADC linker -
HY-136314
DBCO-PEG4-VC-PAB-MMAEDrug-Linker Conjugate for ADC -
HY-141141
Boc-Val-Cit-PABADC Linker -
HY-140150
Azido-PEG3-Val-Cit-PAB-PNPADC Linker -
HY-15575G
VcMMAE (GMP)Drug-Linker Conjugate for ADC
Biological Activity
Description
Chemical Information
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CAS No. 1613321-01-9
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Molecular Weight 518.61
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Formula C24H38N8O5
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SMILES
OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN=[N+]=[N-])=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Azidohexanoyl-Val-Cit-PAB-PNP Related Classifications
HY-151699 Related Classifications
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