-
ADC Linkers Related Products (527)
Related Products (527)
-
NH2-PEG3-Val-Cit-PAB-OH
0 ImagesCat. No.: HY-W800618CAS No.: 2055024-62-7NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
-
(R)-Fmoc-Gly-NHCH2O-CH(cPr)-COOH
0 Images(R)-Fmoc-Gly-NHCH2O-CH(cPr)-COOH (Compound A-99-1) is an ADC linker that can be used for the synthesis of ADCs.
-
Fmoc-Aeg(N3)-OH
0 ImagesFmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis. Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Z-L-Dbu(N3)-OH
0 ImagesCat. No.: HY-151737CAS No.: 1932657-23-2Z-L-Dbu(N3)-OH is a click chemistry reagent containing an Azide. Z-L-Dbu(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
(2R,4S)-H-D-Pro(4-N3)-OH
0 ImagesCat. No.: HY-151760CAS No.: 2137086-50-9(2R,4S)-H-D-Pro(4-N3)-OH is a click chemistry reagent containing an azide group. (2R,4S)-H-D-Pro(4-N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
t-Boc-N-amido-PEG4-Val-Cit
0 ImagesCat. No.: HY-W800837CAS No.: 2231240-82-5t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.
-
12-Azido-dodecanoyl-OSu
0 ImagesCat. No.: HY-151818CAS No.: 2489524-00-512-Azido-dodecanoyl-OSu is a click chemistry reagent containing an azide group. 12-Azido-dodecanoyl-OSu can be used as a hydrophobic bioconjugation linker. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
-
Me-Tet-PEG4-NHS
0 ImagesCat. No.: HY-156313CAS No.: 2143968-22-1
-
N3-1,4-trans-CHC-OH
0 ImagesCat. No.: HY-151731CAS No.: 1931895-14-5N3-1,4-trans-CHC-OH is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
-
NH2-PEG1-Val-Cit-PAB-OH
0 ImagesCat. No.: HY-W800617CAS No.: 2055024-63-8NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker intermediate featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
-
Boc-D-Lys(N3)-OH
0 ImagesCat. No.: HY-151703CAS No.: 1620410-04-9Boc-D-Lys(N3)-OH is a Boc-protected amino acid derivative, can be used as a click chemistry reagent and an intermediate for synthesis of linkers. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
-
N-Boc-MeVal
0 ImagesCat. No.: HY-41062CAS No.: 1268729-59-4N-Boc-MeVal is an ADC linker with BOC protecting group.
-
Boc-L-Aza-OH CHA
0 ImagesCat. No.: HY-151763CAS No.: 2098496-88-7Boc-L-Aza-OH CHA is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
-
Docosanedioic acid (Standard)
0 ImagesCat. No.: HY-W034918RCAS No.: 505-56-6Docosanedioic acid (Standard) is the analytical standard of Docosanedioic acid (HY-W034918). This product is intended for research and analytical applications. Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
-
BCN-exo-PEG2-NH2
0 ImagesCat. No.: HY-156319CAS No.: 1357379-13-5BCN-exo-PEG2-NH2 is an ADC Linker containing 2 PEG units. BCN-exo-PEG2-NH2 contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.
-
BCN-exo-PEG4-NHS
0 ImagesCat. No.: HY-156323BCN-exo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-exo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.
-
N3-Pen-Dtpp
0 ImagesCat. No.: HY-151725CAS No.: 1867129-42-7N3-Pen-Dtpp is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
-
N3-L-Lys(Boc)-OH
0 ImagesCat. No.: HY-151841CAS No.: 333366-32-8N3-L-Lys(Boc)-OH is a click chemistry reagent containing an azide group. N3-L-Lys(Boc)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
DiAz-LacNAc-Oxa
0 ImagesCat. No.: HY-Y2043CAS No.: 3080790-02-6DiAz-LacNAc-Oxa is an ADC linker. This linker contains a disaccharide linker structure for glyco-site specific glycosylation coupling, and an asymmetric biazide group for subsequent click reactions.
