Disulfide Cleavable Linker
Disulfide cleavable linkers provide redox-responsive bonds for drug delivery because extracellular and intracellular glutathione gradients enable selective activation in reductive cytoplasmic environments[1]. Mechanistically, disulfide cleavage can release small-molecule drugs, macromolecule conjugates, or masked bioactive agents after cellular entry[2][3]. In cancer models, disulfide-containing prodrugs, nanoparticles, nanogels, vaccines, and aptamer-drug conjugates have improved controlled release, tumor-cell uptake, or antitumor response[2][4][5][6]. Compared with non-redox-responsive analogues, disulfide-linked systems showed faster drug release, stronger cellular uptake, or higher tumor-selective cytotoxicity in reported experimental models[4][7][8]. For research design, linker electronics, steric hindrance, substituent position, and biorelevant reducing agents such as glutathione should guide stability and cleavage-rate evaluation[2][9].
References:
- [1]. Deng Z, et al. Disulfide-Based Self-Immolative Linkers and Functional Bioconjugates for Biological Applications. Macromol Rapid Commun. 2020 Jan;41(1):e1900531. [Content Brief]
- [2]. Wang Q, et al. Disulfide based prodrugs for cancer therapy. RSC Adv. 2020 Jun 25;10(41):24397-24409. [Content Brief]
- [3]. Yang X, et al. Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery. Med Res Rev. 2020 Nov;40(6):2682-2713. [Content Brief]
- [4]. Conte C, et al. Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments. J Control Release. 2018 May 10;277:126-141. [Content Brief]
- [5]. Kramer K, et al. Intracellular Cleavable CpG Oligodeoxynucleotide-Antigen Conjugate Enhances Anti-tumor Immunity. Mol Ther. 2017 Jan 4;25(1):62-70. [Content Brief]
- [6]. Wu Y, et al. Improvement of Drug Release from an Aptamer Drug Conjugate Using Reductive-sensitive Linkers for Tumor-targeted Drug Delivery. AAPS J. 2025 May 20;27(4):95. [Content Brief]
- [7]. Drude N, et al. Impact of Glutathione Modulation on Stability and Pharmacokinetic Profile of Redox-Sensitive Nanogels. Small. 2018 Apr;14(14):e1704093. [Content Brief]
- [8]. Ai X, et al. Star-shape redox-responsive PEG-sheddable copolymer of disulfide-linked polyethylene glycol-lysine-di-tocopherol succinate for tumor-triggering intracellular doxorubicin rapid release: head-to-head comparison. Macromol Biosci. 2014 Oct;14(10):1415-28. [Content Brief]
- [9]. Phillips DJ, et al. Redox-sensitive materials for drug delivery: targeting the correct intracellular environment, tuning release rates, and appropriate predictive systems. Antioxid Redox Signal. 2014 Aug 10;21(5):786-803. [Content Brief]
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Disulfide Cleavable Linker Related Products (125)
Related Products (125)
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SPDMV-sulfo
0 ImagesCat. No.: HY-129373CAS No.: 2101206-86-2SPDMV-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
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Propargyl-PEG1-SS-alcohol
0 ImagesCat. No.: HY-140108CAS No.: 1391914-41-2Propargyl-PEG1-SS-alcohol is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Amino-SS-PEG12-acid
0 ImagesCat. No.: HY-140097Amino-SS-PEG12-acid is a cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Methyltetrazine-SS-PEG4-Biotin
0 ImagesCat. No.: HY-136035Methyltetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyltetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Methyltetrazine-PEG4-SS-PEG4-methyltetrazine
0 ImagesCat. No.: HY-130943Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Azidoethyl-SS-propionic NHS ester
0 ImagesCat. No.: HY-140102CAS No.: 2243566-44-9Azidoethyl-SS-propionic NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azidoethyl-SS-propionic NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Propargyl-PEG1-SS-PEG1-propargyl
0 ImagesCat. No.: HY-140111CAS No.: 1964503-40-9Propargyl-PEG1-SS-PEG1-propargyl is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG1-SS-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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NO2-SPP-sulfo-Me
0 ImagesCat. No.: HY-129378CAS No.: 890409-87-7NO2-SPP-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC).
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Tetrazine-Ph-OPSS
0 ImagesCat. No.: HY-130928CAS No.: 2739715-26-3Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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SPDP-C6-Gly-Leu-NHS ester
0 ImagesCat. No.: HY-141123SPDP-C6-Gly-Leu-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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(2-pyridyldithio)-PEG4 acid
0 ImagesCat. No.: HY-135964CAS No.: 581065-93-2(2-pyridyldithio)-PEG4 acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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PDP-C1-Ph-Val-Cit
0 ImagesCat. No.: HY-126533CAS No.: 1610769-13-5PDP-C1-Ph-Val-Cit is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
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NO2-SPDMV-sulfo
0 ImagesCat. No.: HY-133549CAS No.: 663599-00-6NO2-SPDMV-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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OPSS-Val-Cit-PAB-OH
0 ImagesCat. No.: HY-141144CAS No.: 3047198-15-9OPSS-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Amino-ethyl-SS-PEG3-NHBoc
0 ImagesCat. No.: HY-140099CAS No.: 2144777-87-5Amino-ethyl-SS-PEG3-NHBoc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Aminoethyl-SS-ethylalcohol
0 ImagesCat. No.: HY-117409CAS No.: 15579-01-8Aminoethyl-SS-ethylalcohol is a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Tetrazine-PEG5-SS-amine
0 ImagesCat. No.: HY-130945Tetrazine-PEG5-SS-amine is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-PEG5-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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THP-SS-alcohol
0 ImagesCat. No.: HY-140122CAS No.: 877864-04-5THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Boc-aminooxy-ethyl-SS-propanol
0 ImagesCat. No.: HY-140117CAS No.: 2128735-21-5Boc-aminooxy-ethyl-SS-propanol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DMAC-SPDB
0 ImagesCat. No.: HY-133550CAS No.: 663599-05-1DMAC-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
