CCR Antagonist

CCR Antagonists (22):

Cat. No.	Product Name	Effect	Purity

HY-148494

Tivumecirnon	Antagonist
Tivumecirnon (FLX475) is an orally active CCR4 antagonist that blocks regulatory T cells from entering the tumor microenvironment, thereby reducing their interference with effective anti-tumor immune responses. Tivumecirnon has antitumor activity.

HY-116835

BI-6901	Antagonist	99.76%
BI 6901 is a potent, selective CCR10 antagonist (pIC₅₀=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research.

HY-112792A

(1S)-CCR2 antagonist 1	Antagonist	98.03%
(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a K_i of 2.4 nM.

HY-103361

SB297006	Antagonist	99.88%
SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

HY-P99697

Leronlimab	Antagonist
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.

HY-153670

IPG7236	Antagonist	98.54%
IPG7236 is a selective CCR8 antagonist. IPG7236 exhibits significant tumor suppression in a mouse xenograft model of human breast cancer. IPG7236 can be used in cancer research.

HY-123763

MLN3126	Antagonist	98.64%
MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC₅₀ value of 6.3 nM for calcium influx.

HY-109511

AZD-1678	Antagonist	98.12%
AZD-1678 is a potent CCR4 receptor antagonist, with a pIC₅₀ of 8.6.

HY-125836

CCR4 antagonist 2	Antagonist
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits T_reg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC₅₀ values of Ca²⁺flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.

HY-114193

CCR1 antagonist 6	Antagonist
CCR1 antagonist 6 (compound 16q) is a chemokine receptor 1 (CCR1) antagonist, with an IC₅₀ of 3 nM.

HY-114194

CCR1 antagonist 7	Antagonist
CCR1 antagonist 7 (compound 16r) is a chemokine receptor 1 (CCR1) antagonist, with an IC₅₀ of 4 nM.

HY-115874

BMS-753426	Antagonist
BMS-753426 is a potent and orally bioavailable antagonist of CCR2.

HY-114097A

CCR1 antagonist 11 hydrochloride	Antagonist
CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC₅₀ values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases.

HY-14231

CCR5 antagonist 5	Antagonist
CCR5 antagonist 5 (compound example 11) is a CCR5 antagonist. CCR5 antagonist 5 has the potential to study inflammation and immunity and viral (such as HIV) infection.

HY-14388

PF-232798	Antagonist
PF-232798 is an orally active CCR5 antagonist with anti-HIV effects.

HY-13245B

(Rac)-PF-4136309	Antagonist	≥98.0%
(Rac)-PF-4136309 is an isoform of PF-4136309 (HY-13245), which is a potent, selective, and orally bioavailable CCR2 antagonist, with IC₅₀s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

HY-P4191

Met-RANTES (human)	Antagonist
Met-RANTES (human) is a partial antagonist of CCR5. Met-RANTES (human) reduces the infiltration of blood monocytes into the liver.

HY-148232

BAY-3153	Antagonist
BAY-3153 is a selective CCR1 (C-C motif chemokine receptor 1) antagonist (human IC₅₀=3 nM; rat IC₅₀=11 nM; mice IC₅₀=81 nM).

HY-13004S

Maraviroc-d₆	Antagonist
Maraviroc-d₆ (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV[1][2].

HY-103360A

cis-J-113863	Antagonist
cis-J-113863 is a competitive chemokine receptor 1 (CCR1) antagonist, with IC₅₀ values of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively.

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