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Cat. No.: HY-123768

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SCH 350581

(Synonyms: AD-101)

SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes.

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CAS No.: 306293-36-7
Formule: C₂₈H₃₇F₃N₄O
Masse moléculaire:502.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

SCH 350581 Chemical Structure

CAS No.: 306293-36-7

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Activité biologique
- Description
- Cellular Effect
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.03 nM Compound: 2	Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5 Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5	[PMID: 12565973]
U-87MG ATCC	IC₅₀	0.2 nM Compound: 2	Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM	[PMID: 12565973]
U-87MG ATCC	IC₅₀	0.5 nM Compound: 18	Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells	[PMID: 11585438]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 306293-36-7
Masse moléculaire 502.61
Formule C₂₈H₃₇F₃N₄O
SMILES

O=C(C1=C(C)C=CN=C1C)N2CCC(N3C[C@H](C)N([C@H](C4=CC=C(C(F)(F)F)C=C4)C)CC3)(C)CC2
Synonyms

AD-101
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tsamis F, et al. Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry. J Virol. 2003 May;77(9):5201-8. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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- Essai clinique
Chemical Information
Pureté et documentation
Références

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SCH 350581

Voir tous les produits spécifiques à Isoform CCR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SCH 350581 Related Classifications

HY-123768 Related Classifications