2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. SCH 350581

SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes.

For research use only. We do not sell to patients.

SCH 350581

SCH 350581 Chemical Structure

CAS No. : 306293-36-7

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SCH 350581 Related Antibodies

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
0.03 nM
Compound: 2
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
[PMID: 12565973]
U-87MG ATCC IC50
0.2 nM
Compound: 2
Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM
Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM
[PMID: 12565973]
U-87MG ATCC IC50
0.5 nM
Compound: 18
Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells
Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells
[PMID: 11585438]
Clinical Trial
Molecular Weight

502.61

Formula

C28H37F3N4O
CAS No.
SMILES

O=C(C1=C(C)C=CN=C1C)N2CCC(N3C[C@H](C)N([C@H](C4=CC=C(C(F)(F)F)C=C4)C)CC3)(C)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCH 350581 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 350581306293-36-7AD-101SCH350581SCH-350581AD101AD 101CCRCC chemokine receptorCCR5 antagonistprimary lymphocytesInhibitorinhibitorinhibit

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