SCH 350581
SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 306293-36-7
- 分子式: C28H37F3N4O
- 分子量:502.61
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
0.03 nM
Compound: 2
|
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
|
[PMID: 12565973] |
| U-87MG ATCC | IC50 |
0.2 nM
Compound: 2
|
Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM
Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM
|
[PMID: 12565973] |
| U-87MG ATCC | IC50 |
0.5 nM
Compound: 18
|
Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells
Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells
|
[PMID: 11585438] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
-
CAS 番号 306293-36-7
-
分子量 502.61
-
分子式 C28H37F3N4O
-
SMILES
O=C(C1=C(C)C=CN=C1C)N2CCC(N3C[C@H](C)N([C@H](C4=CC=C(C(F)(F)F)C=C4)C)CC3)(C)CC2
-
別名
AD-101
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SCH 350581 関連分類
HY-123768 関連分類
Powered by Bioz