1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. BI-6901

BI-6901 

Cat. No.: HY-116835
Handling Instructions

BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research.

For research use only. We do not sell to patients.

BI-6901 Chemical Structure

BI-6901 Chemical Structure

CAS No. : 2040401-92-9

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Description

BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].

In Vivo

BI-6901 (intraperitoneal injection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb-C mice with a DNFB model of contact hypersensitivity.
Dosage: 100 mg/kg
Administration: Intraperitoneal injection
Result: Had a inhibitory effect on the DNFB stimulated inflammatory response in sensitized Balb-c mice.
Molecular Weight

453.56

Formula

C₂₃H₂₇N₅O₃S

CAS No.
SMILES

O=S(C1=CC=CC2=C1C=CN2)(N[[email protected]@H](C(N3CCC(C)CC3)=O)CCN4C(C#N)=CC=C4)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BI-6901BI6901BI 6901CCRCC chemokine receptorCCR10DNFBinflammationchemokineInhibitorinhibitorinhibit

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BI-6901
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HY-116835
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