857679-55-1
Chemical Structure
(Rac)-PF-4136309
Synonym(s): (Rac)-INCB8761
- CAS No.: 857679-55-1
- Formula:C29H31F3N6O3
- Molecular Weight:568.59
IUPAC Name: (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
InChIKey: ZNSVOHSYDRPBGI-CBQRAPNFSA-N
SMILES: O=C(NCC(N1C[C@@H](NC2CCC(C3=NC=C(C4=NC=CC=N4)C=C3)(O)CC2)CC1)=O)C5=CC=CC(C(F)(F)F)=C5
Biological Activity: (Rac)-PF-4136309 is an isoform of PF-4136309 (HY-13245), which is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
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(Rac)-PF-4136309 | (Rac)-PF-4136309 is an isoform of PF-4136309 (HY-13245), which is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. | |||||||||||||||||||||
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Keywords
