AZD-1678
Based on 1 Customer Validation
AZD-1678 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6.
For research use only. We do not sell to patients.
- Purity: 98.65%
- CAS No.: 942137-41-9
- Formula: C11H8Cl2FN3O3S
- Molecular Weight:352.17
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 942137-41-9
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Appearance Solid
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Molecular Weight 352.17
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Formula C11H8Cl2FN3O3S
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Color Off-white to light yellow
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SMILES
O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=C(F)N=C2OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (283.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8395 mL | 14.1977 mL | 28.3954 mL | 70.9884 mL |
| 5 mM | 0.5679 mL | 2.8395 mL | 5.6791 mL | 14.1977 mL | |
| 10 mM | 0.2840 mL | 1.4198 mL | 2.8395 mL | 7.0988 mL | |
| 15 mM | 0.1893 mL | 0.9465 mL | 1.8930 mL | 4.7326 mL | |
| 20 mM | 0.1420 mL | 0.7099 mL | 1.4198 mL | 3.5494 mL | |
| 25 mM | 0.1136 mL | 0.5679 mL | 1.1358 mL | 2.8395 mL | |
| 30 mM | 0.0947 mL | 0.4733 mL | 0.9465 mL | 2.3663 mL | |
| 40 mM | 0.0710 mL | 0.3549 mL | 0.7099 mL | 1.7747 mL | |
| 50 mM | 0.0568 mL | 0.2840 mL | 0.5679 mL | 1.4198 mL | |
| 60 mM | 0.0473 mL | 0.2366 mL | 0.4733 mL | 1.1831 mL | |
| 80 mM | 0.0355 mL | 0.1775 mL | 0.3549 mL | 0.8874 mL | |
| 100 mM | 0.0284 mL | 0.1420 mL | 0.2840 mL | 0.7099 mL |
AZD-1678 Related Classifications
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