2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. AZD-1678

AZD-1678 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6.

For research use only. We do not sell to patients.

AZD-1678 Chemical Structure

AZD-1678 Chemical Structure

CAS No. : 942137-41-9

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1 mg USD 340 In-stock
5 mg USD 850 In-stock
10 mg USD 1100 In-stock
25 mg USD 1650 In-stock
50 mg USD 2145 In-stock
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Based on 1 publication(s) in Google Scholar

AZD-1678 Related Antibodies

Top Publications Citing Use of Products

View All CCR Isoform Specific Products:

View All Isoforms
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

AZD-1678 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6[1].

Molecular Weight

352.17

Formula

C11H8Cl2FN3O3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=C(F)N=C2OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (283.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8395 mL 14.1977 mL 28.3954 mL
5 mM 0.5679 mL 2.8395 mL 5.6791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8395 mL 14.1977 mL 28.3954 mL 70.9884 mL
5 mM 0.5679 mL 2.8395 mL 5.6791 mL 14.1977 mL
10 mM 0.2840 mL 1.4198 mL 2.8395 mL 7.0988 mL
15 mM 0.1893 mL 0.9465 mL 1.8930 mL 4.7326 mL
20 mM 0.1420 mL 0.7099 mL 1.4198 mL 3.5494 mL
25 mM 0.1136 mL 0.5679 mL 1.1358 mL 2.8395 mL
30 mM 0.0947 mL 0.4733 mL 0.9465 mL 2.3663 mL
40 mM 0.0710 mL 0.3549 mL 0.7099 mL 1.7747 mL
50 mM 0.0568 mL 0.2840 mL 0.5679 mL 1.4198 mL
60 mM 0.0473 mL 0.2366 mL 0.4733 mL 1.1831 mL
80 mM 0.0355 mL 0.1775 mL 0.3549 mL 0.8874 mL
100 mM 0.0284 mL 0.1420 mL 0.2840 mL 0.7099 mL
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AZD-1678 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD-1678942137-41-9AZD1678AZD 1678CCRCC chemokine receptorInhibitorinhibitorinhibit

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