2. Signaling Pathways
  3. NF-κB
  4. IKK
  5. TBK1 Isoform
  6. TBK1 Degrader

TBK1 Degrader

TBK1 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-183098
    UNC8209
    		Degrader
    UNC8209 is a selective PROTAC-based TANK-binding kinase 1 (TBK1) degrader. UNC8209 recruits cereblon (CRBN) to mediate ubiquitin-proteasome pathway-dependent TBK1 degradation and reduces AAK1, GAK, and AURKA abundance. UNC8209 suppresses tumor cell proliferation, impairs in vivo tumor growth, inhibits colony and clonogenic growth and enhances tumor cell sensitivity to TNFα or IFN-γ. UNC8209 modulates cell cycle and induces mild apoptosis. UNC8209 can be used for the research of clear cell renal cell carcinoma, non-small cell lung cancer, pancreatic ductal adenocarcinoma.