Lipoxygenase
LOX
Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.
Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.
Lipoxygenase Isoform Specific Products
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Lipoxygenase Inhibitors
(274)
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Lipoxygenase Antagonists
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Lipoxygenase Activators
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Lipoxygenase Modulators
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Lipoxygenase Control
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Lipoxygenase Substrates
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Lipoxygenase Ligand
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Lipoxygenase Related Products (307)
Related Products (307)
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Antibodies (5)
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Lipoxygenase Isoform Comparison
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SB 210661
0 ImagesCat. No.: HY-116080CAS No.: 162750-10-9SB 210661 is a potent and selective 5-lipoxygenase inhibitor.
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Leukotriene A 3 methyl ester
0 ImagesCat. No.: HY-W747562CAS No.: 83851-38-1Leukotriene A 3 methyl ester occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway.
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CMI-392
0 ImagesCat. No.: HY-19205ACAS No.: 193739-23-0Synonyms: LDP-392CMI-392 (LDP-392) is an orally active dual 5-lipoxygenase inhibitor and platelet-activating factor receptor (PAFR) antagonist, with an IC50 of 10 nM for human PAF receptor and an IC50 of 100 nM for rat 5-lipoxygenase. CMI-392 blocks PAF receptor binding, inhibits leukotriene synthesis, attenuates PAF-induced hemoconcentration, and suppresses arachidonic acid- and TPA-induced ear swelling in mice. CMI-392 reduces inflammatory cell infiltration, decreases MPO levels, alleviates ocular inflammation, and improves dextran sulfate sodium-induced colitis. CMI-392 can be used in the research of inflammatory and immune-related diseases such as colitis and atopic dermatitis.
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CMI977
0 ImagesCat. No.: HY-U00260CAS No.: 175212-04-1Synonyms: LDP977CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.
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COX/5-LO-IN-1
0 ImagesCat. No.: HY-U00347CAS No.: 154355-75-6Synonyms: Atreleuton analogCOX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.
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AZD 4407
0 ImagesCat. No.: HY-U00217CAS No.: 166882-70-8Synonyms: ZD 4407AZD 4407 is a potent 5-lipoxygenase inhibitor.
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Bunaprolast
0 ImagesCat. No.: HY-U00170CAS No.: 99107-52-5Synonyms: U66858Bunaprolast (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) also exhibits significant inhibition of lipoxygenase and TXB2 release.
