Monocarboxylate Transporter
Monocarboxylate transporters (MCTs) constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such aslactate and pyruvate, across biological membranes. Highly malignant tumors rely heavily on aerobic glycolysis (metabolism of glucose to lactic acid even under ample tissue oxygen; Warburg Effect) and thus need to efflux lactic acid via MCTs to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from being "pickled to death". The MCTs have been successfully targeted in pre-clinical studies using RNAi and a small-molecule inhibitor alpha-cyano-4-hydroxycinnamic acid (ACCA; CHC) to show that inhibiting lactic acid efflux is a very effective therapeutic strategy against highly glycolytic malignant tumors.
Monocarboxylate Transporter アイソフォーム特異的製品
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Monocarboxylate Transporter 関連製品 (42)
関連製品 (42)
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Monocarboxylate Transporter Isoform Comparison
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α-Cyano-4-hydroxycinnamic acid (Standard)
0 Images別名: α-Cyano-4-hydroxycinnamate (Standard)α-Cyano-4-hydroxycinnamic acid (Standard) is the analytical standard of α-Cyano-4-hydroxycinnamic acid (HY-107641). This product is intended for research and analytical applications. α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications.
