28166-41-8
28166-41-8
Chemical Structure
α-Cyano-4-hydroxycinnamic acid
Synonym(s): α-Cyano-4-hydroxycinnamate
- CAS No.: 28166-41-8
- Formula:C10H7NO3
- Molecular Weight:189.17
IUPAC Name: (E)-2-cyano-3-(4-hydroxyphenyl)acrylic acid
InChIKey: AFVLVVWMAFSXCK-VMPITWQZSA-N
SMILES: O=C(O)/C(C#N)=C/C1=CC=C(O)C=C1
Biological Activity: α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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α-Cyano-4-hydroxycinnamic acid | 99.92% | α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications. | ||||||||||||||||||||
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α-Cyano-4-hydroxycinnamic acid (Standard) | ≥98% | α-Cyano-4-hydroxycinnamic acid (Standard) is the analytical standard of α-Cyano-4-hydroxycinnamic acid (HY-107641). This product is intended for research and analytical applications. α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications. | ||||||||||||||||||||
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α-Cyano-4-hydroxycinnamic acid-d4 | α-Cyano-4-hydroxycinnamic acid-d4 (α-Cyano-4-hydroxycinnamate-d4) is the deuterium labeled α-Cyano-4-hydroxycinnamic acid (HY-107641). α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications. | |||||||||||||||||||||
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AG 99 | AG 99 (Tyrphostin 46), a tyrphostin derivative, is a tyrosine kinase inhibitor that increases sister chromatid exchange frequency in transformed CHO-K1 and primary CHE cells. AG 99 is promising for research of proliferative diseases. | |||||||||||||||||||||
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(E)-AG 99 (Standard) | ≥98% | (E)-AG 99 (Standard) is the analytical standard of (E)-AG 99 (HY-100962). This product is intended for research and analytical applications. (E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor. | ||||||||||||||||||||
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Tyrphostin AG30 | 98.51% | Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts. | ||||||||||||||||||||
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2-Hydroxy-3-(4-hydroxyphenyl)propenoate | 2-Hydroxy-3-(4-hydroxyphenyl)propenoate (4-Hydroxy-enol-phenylpyruvate) is a nucleoside metabolite. | |||||||||||||||||||||
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cis-p-Coumaric acid | 98.33% | cis-p-Coumaric acid (cis-4-Hydroxycinnamic acid) is the cis-form of p-Coumaric acid (HY-N0351), which is higher in viable seeds of groundnuts than in non-viable ones. p-Coumaric acid is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes Apoptosis. | ||||||||||||||||||||
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p-Coumaric acid (Standard) | 99.84% | p-Coumaric acid (Standard) is the analytical standard of p-Coumaric acid. This product is intended for research and analytical applications. p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities. | ||||||||||||||||||||
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p-Coumaric acid-13C3 | p-Coumaric acid-13C3 is the 13C-labeled p-Coumaric acid. p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities. | |||||||||||||||||||||
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p-Hydroxycinnamic acid (Standard) | ≥98% | p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. | ||||||||||||||||||||
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Tyrphostin 8 | 99.10% | Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM). | ||||||||||||||||||||
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4-Chloro-α-cyanocinnamic acid | 99.78% | 4-Chloro-α-cyanocinnamic acid (Cl-CCA) is an advanced, rationally designed MALDI (Matrix-assisted laser desorption ionization) matrix. | ||||||||||||||||||||
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References
- [1]. A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148(1): 85-96. [Content Brief]
- [2]. Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32(6):1845-56. [Content Brief]
