Oxytocin Receptor
OXTR
The oxytocin receptor belongs to the G-protein-coupled seven-transmembrane receptor superfamily. Its main physiological role is regulating the contraction of uterine smooth muscle at parturition and the ejection of milk from the lactating breast. The oxytocin receptors are activated in response to binding oxytocin and a similar nonapeptide, vasopressin. Oxytocin receptor triggers Gi or Gq protein-mediated signaling cascades leading to the regulation of a variety of neuroendocrine and cognitive functions.
Oxytocin is a nonapeptide of the neurohypophyseal protein family that binds specifically to the oxytocin receptor to produce a multitude of central and peripheral physiological responses. In vivo, oxytocin acts as a paracrine and/or autocrine mediator of multiple biological effects. These effects are exerted primarily through interactions with G-protein-coupled oxytocin/vasopressin receptors, which, via Gq and Gi, stimulate phospholipase C-mediated hydrolysis of phosphoinositides.
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Oxytocin Receptor Related Products (84)
Related Products (84)
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Antibodies (2)
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L 156373
0 ImagesCat. No.: HY-124391CAS No.: 122211-29-4L 156373 is a potent oxytocin receptor antagonist with Ki value of 150 nM.
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PF-06655075 TFA
0 ImagesCat. No.: HY-153963APF-06655075 (TFA) is the TFA form of PF-06655075 (HY-153963). PF-06655075 is a novel andnon–brain-penetrant oxytocin receptor agonist with increased selectivity for the oxytocin receptor and significantly increased pharmacokinetic stability. PF-06655075 can be used as a tool compound to further explore the role of peripheral oxytocin in behavioral response.
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SSR126768A free base
0 ImagesCat. No.: HY-15018ACAS No.: 785048-28-4SSR126768A free base is an orally active antagonist for oxytocin receptor, with Ki of 0.44 nM. SSR126768A free base is a tocolytic agent, that antagonizes the Oxytocin (HY-17571)-induced intracellular Ca2+ increase and prostaglandin release in human uterine smooth muscle cells, inhibits thus the Oxytocin (HY-17571)-induced uterine contraction and delays parturition in pregnant rats in labor.
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OT antagonist 1
0 ImagesCat. No.: HY-103650CAS No.: 479080-38-1OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
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Carbetocin-d7
0 ImagesCat. No.: HY-17573SCarbetocin-d7 is the deuterium labeled Carbetocin (HY-17573). Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS.
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(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin
0 ImagesCat. No.: HY-P2014CAS No.: 114056-26-7(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior.
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Merotocin
0 ImagesCat. No.: HY-P0077CAS No.: 1190083-57-8Merotocin is a selective, short-acting peptidic oxytocin receptor agonist. Merotocin can be used to support lactation.
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OT antagonist 1 demethyl derivative
0 ImagesCat. No.: HY-103651CAS No.: 2763705-17-3OT antagonist 1 demethyl derivative is the demethyl derivative of OT antagonist 1. OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
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Epelsiban besylate
0 ImagesCat. No.: HY-105018ACAS No.: 1159097-48-9Synonyms: GSK 557296 benzenesulfonateEpelsiban Besylate (GSK 557296 benzenesulfonate) is an orally active compound known for its highly selective oxytocin receptor antagonist.
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ALS-I-41
0 ImagesCat. No.: HY-117637CAS No.: 1369357-99-2ALS-I-41 is a novel, potent and selective oxytocin receptor antagonist with the potential to modulate biological activities related to social behavior and mental disorders. ALS-I-41 is being evaluated for behavioral pharmacology experiments in non-human primates and can be administered via intranasal or intramuscular injection. The central nervous system penetration and metabolic rate of ALS-I-41 were studied by mass spectrometry analysis in cerebrospinal fluid and plasma of macaque monkeys.
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Kalata B7
0 ImagesCat. No.: HY-P10325CAS No.: 339532-29-5Kalata B7 is a cyclotide that can be isolated from Oldenlandia affinis DC (Rubiaceae) and possesses membrane-permeating capabilities. Kalata B7 is also a partial agonist of oxytocin and vasopressin V1a receptors.
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(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
0 ImagesCat. No.: HY-P4397CAS No.: 115499-13-3(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, an oxytocin receptor antagonist, abolishes oxytocin-enhanced inhibitory postsynaptic currents in CA1 pyramidal neurons.
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(E/Z)-OT-R antagonist 1
0 ImagesCat. No.: HY-15016CAS No.: 364076-99-3(E/Z)-OT-R antagonist 1 is a mixture of E/Z forms of OT-R antagonist 1 (HY-15015). OT-R antagonist 1 is a novel, potent, selective non-peptide OT-R antagonist that inhibits oxytocin-induced intracellular Ca2+ activation (IC50 = 8 nM).
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L-367773
0 ImagesCat. No.: HY-129791CAS No.: 152140-41-5L-367773 is an orally active, selective oxytocin receptor antagonist, with Ki values of 26 nM and 61 nM for rat uterine oxytocin receptor and human uterine oxytocin receptor, respectively. L-367773 inhibits Oxytocin-stimulated uterine contractions.
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Atosiban (Standard)
0 ImagesCat. No.: HY-17572RCAS No.: 90779-69-4Synonyms: RW22164 (Standard); RWJ22164 (Standard)Atosiban (Standard) is the analytical standard of Atosiban. This product is intended for research and analytical applications. Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.
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L-364918
0 ImagesCat. No.: HY-129333CAS No.: 122211-31-8L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with Ki values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance.
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Cligosiban (Standard)
0 ImagesSynonyms: PF-3274167 (Standard)Cligosiban (Standard) is the analytical standard of Cligosiban. This product is intended for research and analytical applications. Cligosiban (PF-3274167) is an orally active, highly selective, and centrally permeable oxytocin receptor antagonist with good pharmacokinetics in rats and can inhibit physiological ejaculation in rodents.
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L-368,899 hydrochloride (Standard)
0 ImagesCat. No.: HY-108677RCAS No.: 160312-62-9L-368,899 hydrochloride (Standard) is the analytical standard of L-368,899 hydrochloride (HY-108677). This product is intended for research and analytical applications. L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. L-368,899 hydrochloride used as a tocolytic agent.
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OT-R agonist 1 TFA
0 ImagesCat. No.: HY-172814ACAS No.: 3039925-73-7OT-R agonist 1 TFA (compound 5) is an oxytocin receptor agonist with an EC50 of 0.39 nM. OT-R agonist 1 TFA shows V1A antagonist activity with an EC50 of 2432 nM and can be used for study of CNS disorders.
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L-365209
0 ImagesCat. No.: HY-120585CAS No.: 122211-30-7L-365209 is a oxytocin antagonist and can be isolated from Streptomyces .
