PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Octa-1,7-diyne
0 ImagesCat. No.: HY-W267762CAS No.: 871-84-1
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tert-Butyl 20-bromoicosanoate
0 ImagesCat. No.: HY-W614704CAS No.: 1642333-07-0
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1-Boc-4-(4-Carboxybenzyl)piperazine
0 ImagesCat. No.: HY-W102044CAS No.: 479353-63-4
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6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate
![6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate](https://file.medchemexpress.com/product_pic/hy-w058292.gif "Click to View 6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate Product Detail")
0 ImagesCat. No.: HY-W058292CAS No.: 203662-61-7
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N1,N4-Dimethylbutane-1,4-diamine
0 ImagesCat. No.: HY-W088621CAS No.: 16011-97-5
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tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W102095CAS No.: 138227-63-1
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Thalidomide-O-PEG4-acid
0 ImagesCat. No.: HY-W800655CAS No.: 2446382-02-9Thalidomide-O-PEG4-Acid is a PROTAC linker that can react with Amine containing moiety in the presence of Activator EDC or HATU.
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(S,E)-TCO2-PEG3-acid
0 ImagesCat. No.: HY-140015A
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Methyl 2-[3-(aminomethyl)cyclobutyl]acetate hydrochloride
![Methyl 2-[3-(aminomethyl)cyclobutyl]acetate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w057330.gif "Click to View Methyl 2-[3-(aminomethyl)cyclobutyl]acetate hydrochloride Product Detail")
0 ImagesCat. No.: HY-W057330CAS No.: 1638765-19-1
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2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)acetic acid
0 ImagesCat. No.: HY-W986741CAS No.: 909282-26-4
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Methyl 10-hydroxydecanoate
0 ImagesCat. No.: HY-W404252CAS No.: 2640-94-0
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Benzyl 5-hydroxypentanoate
0 ImagesCat. No.: HY-W130690CAS No.: 134848-96-7
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Hex-3-enedinitrile
0 ImagesCat. No.: HY-W130918ACAS No.: 1119-85-3
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4-(Azetidin-3-yl)piperazin-2-one hydrochloride
0 ImagesCat. No.: HY-W612110CAS No.: 1624260-62-3
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4-Bromobutyl acetate
0 ImagesCat. No.: HY-W130241CAS No.: 4753-59-7
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5-Aminopentanoic acid hydrochloride
0 ImagesCat. No.: HY-W111909CAS No.: 627-95-2
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endo-BCN-PEG3-NHS ester
0 ImagesCat. No.: HY-140068CAS No.: 2141976-24-9
