PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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22-Bromodocosanoic acid
0 ImagesCat. No.: HY-W460259CAS No.: 78774-39-7
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4-Azidobutylamine (Standard)
0 ImagesCat. No.: HY-108374RCAS No.: 88192-20-54-Azidobutylamine (Standard) is the analytical standard of 4-Azidobutylamine (HY-108374). This product is intended for research and analytical applications. 4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate
![tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w613883.gif "Click to View tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W613883CAS No.: 122632-07-9
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tert-Butyl (3-aminopropyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W000835CAS No.: 127346-48-9
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Cbz-NH-C4-O-NH2
0 ImagesCat. No.: HY-W415279CAS No.: 1359993-60-4
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p-Phenylenedipropionicacid
0 ImagesCat. No.: HY-W104919CAS No.: 4251-21-2Synonyms: p-Phenylenedipropionic acid
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Tert-butyl 4-((1r,4r)-4-aminocyclohexyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W380868CAS No.: 876371-20-9
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Boc-C-PEG3-I
0 ImagesCat. No.: HY-W577130CAS No.: 2162121-00-6
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tert-Butyl 4-(azetidin-3-yl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W056396CAS No.: 1314703-47-3
![Boc-NH-(1-Methylbicyclo[2.2.2]octane)-amino](https://file.medchemexpress.com/product_pic/hy-w358273.gif "Click to View Boc-NH-(1-Methylbicyclo[2.2.2]octane)-amino Product Detail")
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Piperazin-C-benzoic acid dihydrochloride
0 ImagesCat. No.: HY-W104938CAS No.: 86620-70-4
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1,13-Dibromotridecane
0 ImagesCat. No.: HY-W1009568CAS No.: 31772-05-1
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Piperidine-4-carbaldehyde
0 ImagesCat. No.: HY-W012935CAS No.: 50675-20-2Synonyms: Piperidine-4-carboxaldehydePiperidine-4-carbaldehyde (Piperidine-4-carboxaldehyde) is a PROTAC Linker. Piperidine-4-carbaldehyde can be used to optimize combined with the target protein affinity, thus improve the PROTAC the molecular degradation efficiency. Piperidine-4-carbaldehyde can be used in the CDK2 PROTACs (HY-161708).
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BnO-PEG3-COOH
0 ImagesCat. No.: HY-W335398CAS No.: 144751-75-7
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Tert-butyl (5-aminopentyl)(methyl)carbamate
0 ImagesCat. No.: HY-W419958CAS No.: 1228544-59-9
