PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen
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PROTAC Linkers Verwandte Produkte (4102)
Verwandte Produkte (4102)
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PROTAC Linkers Isoform Comparison
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Methyl-PEG3-Ald
0 ImagesArt. -Nr.: HY-132092CAS. Nr.: 141981-62-6
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THP-PEG5-OH
0 ImagesArt. -Nr.: HY-126917CAS. Nr.: 146395-14-4
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Mal-PEG2-PFP ester
0 ImagesArt. -Nr.: HY-130416CAS. Nr.: 1807512-47-5
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N-Me-N-bis(PEG2-propargyl)
0 ImagesArt. -Nr.: HY-140043CAS. Nr.: 1835759-84-6
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Fmoc-Val-Phe-Boc
0 ImagesArt. -Nr.: HY-46398CAS. Nr.: 258879-48-0Fmoc-Val-Phe-Boc is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Val-Phe-Boc can be used in the synthesis of the Deruxtecan.
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S-acetyl-PEG4-amine
0 ImagesArt. -Nr.: HY-138752CAS. Nr.: 1404111-71-2
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F-PEG2-COOH
0 ImagesArt. -Nr.: HY-138498CAS. Nr.: 2383964-72-3
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Thiol-PEG3-phosphonic acid
0 ImagesArt. -Nr.: HY-141318CAS. Nr.: 1360716-36-4
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Bis-Mal-Lysine-PEG4-acid
0 ImagesArt. -Nr.: HY-141001CAS. Nr.: 1426164-52-4
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THP-PEG1-THP
0 ImagesArt. -Nr.: HY-138531CAS. Nr.: 71033-27-7
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Biotin-PEG4-allyl
0 ImagesArt. -Nr.: HY-138426CAS. Nr.: 1643661-79-3
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N-(Azido-PEG2)-N-Boc-PEG4-Boc
0 ImagesArt. -Nr.: HY-140563CAS. Nr.: 2093153-83-2N-(Azido-PEG2)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Boc-NH-PEG8-propargyl
0 ImagesArt. -Nr.: HY-140883CAS. Nr.: 2183440-31-3
