PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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(+)-Biotin-PEG6-hydrazide
0 ImagesCat. No.: HY-130891CAS No.: 2601437-70-9
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COOH-C-PEG2-NHCO-C2-COOH
0 ImagesCat. No.: HY-169236CAS No.: 947504-71-4
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Azido-PEG1-CH2CO2-NHS
0 ImagesCat. No.: HY-140763CAS No.: 1480545-09-2Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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S-acetyl-PEG6-Boc
0 ImagesCat. No.: HY-141348CAS No.: 1818294-39-1
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Dimethylamino-PEG2-C2-NH2
0 ImagesCat. No.: HY-W096132CAS No.: 692782-62-0
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Bis-PEG11-acid
0 ImagesCat. No.: HY-141019CAS No.: 2097010-30-3
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Boc-NH-PEG6-propargyl
0 ImagesCat. No.: HY-140881CAS No.: 1262991-52-5
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Boc-aminooxy-PEG4-propargyl
0 ImagesCat. No.: HY-140052CAS No.: 1895922-77-6
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Boc-HyNic-PEG2-N3
0 ImagesCat. No.: HY-133501CAS No.: 2742971-89-5Boc-HyNic-PEG2-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-HyNic-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Aniline-piperazine-C3-NH-Boc
0 ImagesCat. No.: HY-133702CAS No.: 643087-19-8Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker, and can be used for synthesis of Pomalidomide-C3-adavosertib (HY-133618) and AZD1775 (HY-10993) (a Wee1 inhibitor).
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m-PEG9-t-Butyl ester
0 ImagesCat. No.: HY-141398CAS No.: 2768015-30-9Synonyms: Methyl-PEG9-t-butyl ester
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N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5
0 ImagesCat. No.: HY-141041CAS No.: 2107273-42-5N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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PEG2-bis(phosphonic acid diethyl ester)
0 ImagesCat. No.: HY-141320CAS No.: 500347-73-9
