PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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PEG2-bis(phosphonic acid diethyl ester)
0 ImagesCat. No.: HY-141320CAS No.: 500347-73-9
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Me-PEG4-Me (Standard)
0 ImagesSynonyms: Tetraglyme (Standard)
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t-Boc-Aminooxy-PEG8-alcohol
0 ImagesCat. No.: HY-140424CAS No.: 2353410-14-5
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Mal-PEG16-NHS ester
0 ImagesCat. No.: HY-W019794
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m-PEG7-CH2-OH
0 ImagesCat. No.: HY-133058CAS No.: 1807512-35-1
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Hydroxy-PEG4-CH2COOH sodium salt
0 ImagesCat. No.: HY-W800630CAS No.: 73349-20-9
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Acryloyl-PEG4-OH
0 ImagesCat. No.: HY-138423CAS No.: 26150-06-1
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Boc-PEG4-sulfonic acid
0 ImagesCat. No.: HY-140174CAS No.: 1817735-26-4
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Benzyl-PEG8-Ots
0 ImagesCat. No.: HY-138711CAS No.: 1144113-17-6
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Azido-PEG3-Sulfone-PEG4-Boc
0 ImagesCat. No.: HY-140604CAS No.: 2055023-76-0Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Boc-PEG16-alcohol
0 ImagesCat. No.: HY-141194CAS No.: 2592432-32-9
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1-(Azetidin-3-yl)azetidine
0 ImagesCat. No.: HY-W125996CAS No.: 928114-07-2Synonyms: 1-(3-Azetidinyl)-azetidine
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Propargyl-PEG12-amine
0 ImagesCat. No.: HY-140034CAS No.: 2264091-73-6
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BnO-PEG1-CH2COOH
0 ImagesCat. No.: HY-121957CAS No.: 93206-09-8
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N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl)
0 ImagesCat. No.: HY-140092CAS No.: 2112737-60-5N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
