PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers アイソフォーム特異的製品
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PROTAC Linkers 関連製品 (4102)
関連製品 (4102)
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PROTAC Linkers Isoform Comparison
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N-(m-PEG4)-N'-(azide-PEG4)-Cy7
0 Images製品番号: HY-141078CAS 番号: 2107273-40-3N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Boc-N-Amido-PEG3-azide
0 Images製品番号: HY-140835CAS 番号: 642091-68-7Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-N-Amido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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NH-bis(PEG3-acid)
0 Images製品番号: HY-140515CAS 番号: 1814901-04-6
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Pyrene azide 3
0 Images製品番号: HY-D1295CAS 番号: 2252168-06-0Pyrene azide 3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Pyrene azide 3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Boc-PEG4)-NH-PEG4-NH-Boc
0 Images製品番号: HY-140259CAS 番号: 2112737-17-2
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Alkyne-ethyl-PEG1-Boc
0 Images製品番号: HY-140032CAS 番号: 2100306-55-4別名: Alkyne-ethyl-PEG1-t-butyl ester
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Boc-NHCH2CH2-PEG1-azide
0 Images製品番号: HY-132119CAS 番号: 176220-30-7Boc-NHCH2CH2-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NHCH2CH2-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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S-acetyl-PEG4-NHBoc
0 Images製品番号: HY-138755CAS 番号: 1404111-70-1
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Boc-Aminooxy-PEG3-thiol
0 Images製品番号: HY-140439CAS 番号: 1895922-75-4
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N,N'-DME-N,N'-Bis-PEG2-acid
0 Images製品番号: HY-141028CAS 番号: 2062663-61-8
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Benzyl-PEG1-propanol
0 Images製品番号: HY-138433CAS 番号: 131326-24-4
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Benzyl-PEG6-THP
0 Images製品番号: HY-132105CAS 番号: 230620-73-2
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m-PEG10-Tos
0 Images製品番号: HY-140360CAS 番号: 211859-75-5
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Azido-PEG13-azide
0 Images製品番号: HY-132059Azido-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG13-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Tetrazine-Ph-NHCO-PEG6-NH-Boc
0 Images製品番号: HY-133461Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Azido-PEG3-CH2CO2Me
0 Images製品番号: HY-140853CAS 番号: 1253389-31-9Azido-PEG3-CH2CO2Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-CH2CO2Me is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Chloroacetamido-C-PEG3-C3-NHBoc
0 Images製品番号: HY-W096151CAS 番号: 934164-55-3
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Methyl acetate-PEG2-propanol
0 Images製品番号: HY-138462CAS 番号: 3026669-97-3
