PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Benzyl-PEG2-ethanol
0 ImagesCat. No.: HY-138479CAS No.: 2055300-50-8
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Azide-PEG6-amido-C16-Boc
0 ImagesCat. No.: HY-140787Synonyms: 17-(Azide-PEG6-ethylcarbamoyl)heptadecanoic t-butyl esterAzide-PEG6-amido-C16-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG6-amido-C16-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Boc-NH-PEG6-azide
0 ImagesCat. No.: HY-140838CAS No.: 1292268-15-5Boc-NH-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Tos-PEG12-Tos
0 ImagesCat. No.: HY-140371CAS No.: 1456708-45-4
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m-PEG5-MS
0 ImagesCat. No.: HY-116186CAS No.: 130955-38-3m-PEG5-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Acid-PEG13-NHS ester
0 ImagesCat. No.: HY-141097CAS No.: 2152679-62-2
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Azide-PEG9-amido-C8-Boc
0 ImagesCat. No.: HY-140789Synonyms: 9-(Azide-PEG9-ethylcarbamoyl)nonanoic t-butyl esterAzide-PEG9-amido-C8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG9-amido-C8-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Azido-PEG3)-N-Boc-PEG3-NHS ester
0 ImagesCat. No.: HY-140561CAS No.: 2112731-51-6N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG1-C2-methylamine
0 ImagesCat. No.: HY-140221CAS No.: 1835759-88-0Azido-PEG1-C2-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C2-methylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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I-PEG6-OH
0 ImagesCat. No.: HY-W096156CAS No.: 136399-07-0
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Propargyl-PEG4-tetra-Ac-beta-D-glucose
0 ImagesCat. No.: HY-141133CAS No.: 1360446-31-6
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Amino-PEG11-OH
0 ImagesCat. No.: HY-130298CAS No.: 15332-94-2Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Mal-PEG3-alcohol
0 ImagesCat. No.: HY-140969CAS No.: 146551-23-7
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THP-PEG1-Boc
0 ImagesCat. No.: HY-138368CAS No.: 2923507-24-6
