PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Propargyl-PEG4-beta-D-glucose
0 ImagesCat. No.: HY-141132CAS No.: 1397682-63-1
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Boc-Aminooxy-PEG3-bromide
0 ImagesCat. No.: HY-140435CAS No.: 918132-15-7
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1-(2-Chloro-acetyl)-piperazine
0 ImagesCat. No.: HY-W803227CAS No.: 145222-00-0
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Benzyl-PEG6-bromide
0 ImagesCat. No.: HY-132028CAS No.: 1449202-44-1
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Azido-PEG5-CH2CO2-PFP
0 ImagesCat. No.: HY-130693CAS No.: 2144777-92-2Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG5-CH2CO2-PFP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Azido-PEG3)-N-bis(PEG3-Boc)
0 ImagesCat. No.: HY-140868CAS No.: 2055042-56-1N-(Azido-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG3-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Fmoc-N-PEG3-CH2-NHS ester
0 ImagesCat. No.: HY-135029CAS No.: 2128735-25-9
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Br-PEG3-CH2COOH
0 ImagesCat. No.: HY-130500CAS No.: 1346502-15-5
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Methylamino-PEG3-t-butyl ester
0 ImagesCat. No.: HY-132071CAS No.: 217817-03-3
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Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite
0 ImagesCat. No.: HY-W096140CAS No.: 1682657-14-2Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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m-PEG3-Sulfone-PEG3-Boc
0 ImagesCat. No.: HY-140609CAS No.: 2055041-00-2
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Diethyl 8-bromooctylphosphonate
0 ImagesCat. No.: HY-140332CAS No.: 124939-70-4
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N-(m-PEG4)-N'-(PEG2-acid)-Cy5
0 ImagesCat. No.: HY-141035CAS No.: 2107273-24-3
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Azido-PEG3-S-PEG4-t-butyl ester
0 ImagesCat. No.: HY-140592CAS No.: 2055041-19-3Azido-PEG3-S-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-S-PEG4-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Boc-PEG2-ethoxyethane-PEG2-benzyl
0 ImagesCat. No.: HY-138475CAS No.: 2111836-22-5
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C-NH-Boc-C-Bis-(C1-PEG1-PFP)
0 ImagesCat. No.: HY-141259CAS No.: 1807521-01-2
